ArticlePloS one2011
Genetic determinants of cardiovascular events among women with migraine: a genome-wide association study.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 25 citations in OpenAlex.
- Amyloid-beta metabolism in age-related neurocardiovascular diseases.European heart journal · 2025Review
- Small RNA signatures of acute ischemic stroke in L1CAM positive extracellular vesicles.Scientific reports · 2024Article
- Proteomic Signature of Subclinical Coronary Artery Disease in People With HIV: Analysis of the REPRIEVE Mechanistic Substudy.The Journal of infectious diseases · 2022 · on this mapArticle
- Advancing stroke genomic research in the age of Trans-Omics big data science: Emerging priorities and opportunities.Journal of the neurological sciences · 2017Review
- Migraine and Stroke: What's the Link? What to Do?Current neurology and neuroscience reports · 2017Review
- Migraine and risk of cardiovascular disease in women: prospective cohort study.BMJ (Clinical research ed.) · 2016Article
- Altering 5-hydroxymethylcytosine modification impacts ischemic brain injury.Human molecular genetics · 2015Article
- Genetics of diabetes complications.Mammalian genome : official journal of the International Mammalian Genome Society · 2014Review
- Interaction among nitric oxide (NO)-related genes in migraine susceptibility.Molecular and cellular biochemistry · 2012Article
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Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
Abstract
backgroundMigraine is associated with an increased risk for cardiovascular disease (CVD). Both migraine and CVD are highly heritable. However, the genetic liability for CVD among migraineurs is unclear.
methodsWe performed a genome-wide association study for incident CVD events during 12 years of follow-up among 5,122 migraineurs participating in the population-based Women's Genome Health Study. Migraine was self-reported and CVD events were confirmed after medical records review. We calculated odds ratios (OR) and 95% confidence intervals (CI) and considered a genome-wide p-value <5×10(-8) as significant.
resultsAmong the 5,122 women with migraine 164 incident CVD events occurred during follow-up. No SNP was associated with major CVD, ischemic stroke, myocardial infarction, or CVD death at the genome-wide level; however, five SNPs showed association with p<5×10(-6). Among migraineurs with aura rs7698623 in MEPE (OR = 6.37; 95% CI 3.15-12.90; p = 2.7×10(-7)) and rs4975709 in IRX4 (OR = 5.06; 95% CI 2.66-9.62; p = 7.7×10(-7)) appeared to be associated with ischemic stroke, rs2143678 located close to MDF1 with major CVD (OR = 3.05; 95% CI 1.98-4.69; p = 4.3×10(-7)), and the intergenic rs1406961 with CVD death (OR = 12.33; 95% CI 4.62-32.87; p = 5.2×10(-7)). Further, rs1047964 in BACE1 appeared to be associated with CVD death among women with any migraine (OR = 4.67; 95% CI 2.53-8.62; p = 8.0×10(-7)).
conclusionOur results provide some suggestion for an association of five SNPs with CVD events among women with migraine; none of the results was genome-wide significant. Four associations appeared among migraineurs with aura, two of those with ischemic stroke. Although our population is among the largest with migraine and incident CVD information, these results must be treated with caution, given the limited number of CVD events among women with migraine and the low minor allele frequencies for three of the SNPs. Our results await independent replication and should be considered hypothesis generating for future research.
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