ArticlePloS one2011
E-cadherin acts as a regulator of transcripts associated with a wide range of cellular processes in mouse embryonic stem cells.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 33 citations in OpenAlex.
- EP300 genomic redistribution following E-cadherin inhibition in MCF7 cancer cells: evidence for early epigenetic reprogramming.Histochemistry and cell biology · 2025Article
- The Modulation of Cell Plasticity by Budesonide: Beyond the Metabolic and Anti-Inflammatory Actions of Glucocorticoids.Pharmaceutics · 2025Review
- Recording morphogen signals reveals mechanisms underlying gastruloid symmetry breaking.Nature cell biology · 2024Article
- Cell-cell adhesions in embryonic stem cells regulate the stability and transcriptional activity of β-catenin.FEBS letters · 2022Article
- Interactions and Feedbacks in E-Cadherin Transcriptional Regulation.Frontiers in cell and developmental biology · 2021Article
- Review
- Novel peptides for deciphering structural and signalling functions of E-cadherin in mouse embryonic stem cells.Scientific reports · 2017Article
- Article
- Article
- From cell membrane to the nucleus: an emerging role of E-cadherin in gene transcriptional regulation.Journal of cellular and molecular medicine · 2014Review
- Antioxidants maintain E-cadherin levels to limit Drosophila prohemocyte differentiation.PloS one · 2014Article
- Drosophila E-cadherin functions in hematopoietic progenitors to maintain multipotency and block differentiation.PloS one · 2013Article
- Adherens junctions and stem cells.Sub-cellular biochemistry · 2012Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
backgroundWe have recently shown that expression of the cell adhesion molecule E-cadherin is required for LIF-dependent pluripotency of mouse embryonic stem (ES) cells. METHODOLOGY: In this study, we have assessed global transcript expression in E-cadherin null (Ecad-/-) ES cells cultured in either the presence or absence of LIF and compared these to the parental cell line wtD3.
resultsWe show that LIF has little effect on the transcript profile of Ecad-/- ES cells, with statistically significant transcript alterations observed only for Sp8 and Stat3. Comparison of Ecad-/- and wtD3 ES cells cultured in LIF demonstrated significant alterations in the transcript profile, with effects not only confined to cell adhesion and motility but also affecting, for example, primary metabolic processes, catabolism and genes associated with apoptosis. Ecad-/- ES cells share similar, although not identical, gene expression profiles to epiblast-derived pluripotent stem cells, suggesting that E-cadherin expression may inhibit inner cell mass to epiblast transition. We further show that Ecad-/- ES cells maintain a functional β-catenin pool that is able to induce β-catenin/TCF-mediated transactivation but, contrary to previous findings, do not display endogenous β-catenin/TCF-mediated transactivation. We conclude that loss of E-cadherin in mouse ES cells leads to significant transcript alterations independently of β-catenin/TCF transactivation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.