ArticleFrontiers in neuroinformatics2011
Potential Synaptic Connectivity of Different Neurons onto Pyramidal Cells in a 3D Reconstruction of the Rat Hippocampus.
Article in Frontiers in neuroinformatics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Visualization and simulation of full-scale point-neuron circuits via the Neural Circuit Visualizer web platform.Scientific reports · 2026Article
- Optical Recordings of Unitary Synaptic Connections Reveal High and Random Local Connectivity between CA3 Pyramidal Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Local Microtubule and F-Actin Distributions Fully Constrain the Spatial Geometry ofInternational journal of molecular sciences · 2023Article
- Connectomes: from a sparsity of networks to large-scale databases.Frontiers in neuroinformatics · 2023Review
- Efficient metadata mining of web-accessible neural morphologies.Progress in biophysics and molecular biology · 2022Article
- A Method for Estimating the Potential Synaptic Connections Between Axons and Dendrites From 2D Neuronal Images.Bio-protocol · 2021Article
- Comprehensive Estimates of Potential Synaptic Connections in Local Circuits of the Rodent Hippocampal Formation by Axonal-Dendritic Overlap.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Neuronal classification from network connectivity via adjacency spectral embedding.Network neuroscience (Cambridge, Mass.) · 2021Article
- Efficient Generation of CA3 Neurons from Human Pluripotent Stem Cells Enables Modeling of Hippocampal Connectivity In Vitro.Cell stem cell · 2018Article
- Molecular fingerprinting of principal neurons in the rodent hippocampus: A neuroinformatics approach.Journal of pharmaceutical and biomedical analysis · 2017Article
- Weighing the Evidence in Peters' Rule: Does Neuronal Morphology Predict Connectivity?Trends in neurosciences · 2017Review
- Article
- Alterations in hippocampal connectivity across the psychosis dimension.Psychiatry research · 2015Article
- Quantitative investigations of axonal and dendritic arbors: development, structure, function, and pathology.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2015Review
- Developmental time windows for axon growth influence neuronal network topology.Biological cybernetics · 2015Article
- A neural mechanism for background information-gated learning based on axonal-dendritic overlaps.PLoS computational biology · 2015Article
- A 3-D admittance-level computational model of a rat hippocampus for improving prosthetic design.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2015Article
- Statistical analysis and data mining of digital reconstructions of dendritic morphologies.Frontiers in neuroanatomy · 2014Article
- Parametric Anatomical Modeling: a method for modeling the anatomical layout of neurons and their projections.Frontiers in neuroanatomy · 2014Article
- Versatile morphometric analysis and visualization of the three-dimensional structure of neurons.Neuroinformatics · 2013Article
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2 authors.
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Abstract
Most existing connectomic data and ongoing efforts focus either on individual synapses (e.g., with electron microscopy) or on regional connectivity (tract tracing). An individual pyramidal cell (PC) extends thousands of synapses over macroscopic distances (∼cm). The contrasting requirements of high-resolution and large field of view make it too challenging to acquire the entire synaptic connectivity for even a single typical cortical neuron. Light microscopy can image whole neuronal arbors and resolve dendritic branches. Analyzing connectivity in terms of close spatial appositions between axons and dendrites could thus bridge the opposite scales, from synaptic level to whole systems. In the mammalian cortex, structural plasticity of spines and boutons makes these "potential synapses" functionally relevant to learning capability and memory capacity. To date, however, potential synapses have only been mapped in the surrounding of a neuron and relative to its local orientation rather than in a system-level anatomical reference. Here we overcome this limitation by estimating the potential connectivity of different neurons embedded into a detailed 3D reconstruction of the rat hippocampus. Axonal and dendritic trees were oriented with respect to hippocampal cytoarchitecture according to longitudinal and transversal curvatures. We report the potential connectivity onto PC dendrites from the axons of a dentate granule cell, three CA3 PCs, one CA2 PC, and 13 CA3b interneurons. The numbers, densities, and distributions of potential synapses were analyzed in each sub-region (e.g., CA3 vs. CA1), layer (e.g., oriens vs. radiatum), and septo-temporal location (e.g., dorsal vs. ventral). The overall ratio between the numbers of actual and potential synapses was ∼0.20 for the granule and CA3 PCs. All potential connectivity patterns are strikingly dependent on the anatomical location of both pre-synaptic and post-synaptic neurons.
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