ArticlePLoS pathogens2011
The impact of recombination on dN/dS within recently emerged bacterial clones.
Article in PLoS pathogens, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
68 citing papers in PubMed, 89 citations in OpenAlex.
- Recombination shapes the dynamics of selective constraint in global populations of human gut bacteria.PLoS biology · 2026Article
- Pan-genome insights into genetic diversity, evolutionary dynamics, and pathogenic traits of Staphylococcus agnetis.BMC genomics · 2026Article
- Dynamics of dN/dS within recombining bacterial populations.bioRxiv : the preprint server for biology · 2025Article
- Leveraging FracMinHash Containment for GenomicbioRxiv : the preprint server for biology · 2025Article
- Within-host genomic evolution of methicillin-resistant Staphylococcus aureus in long-term carriers.Applied microbiology and biotechnology · 2024Article
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- Reversions mask the contribution of adaptive evolution in microbiomes.bioRxiv : the preprint server for biology · 2024Article
- Unveiling intraspecific diversity and evolutionary dynamics of the foodborne pathogenCurrent research in food science · 2024Article
- Evaluation of recombination detection methods for viral sequencing.Virus evolution · 2023Article
- Genomics and pathotypes of the many faces of Escherichia coli.FEMS microbiology reviews · 2022Article
- Mosaic Evolution of Beta-Barrel-Porin-Encoding Genes inApplied and environmental microbiology · 2022Article
- Horizontal gene transfer and adaptive evolution in bacteria.Nature reviews. Microbiology · 2022Review
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- Quantifying bacterial evolution in the wild: A birthday problem for Campylobacter lineages.PLoS genetics · 2021Article
- Nonsynonymous Polymorphism Counts in Bacterial Genomes: a Comparative Examination.Applied and environmental microbiology · 2020Article
- Antagonistic pleiotropy conceals molecular adaptations in changing environments.Nature ecology & evolution · 2020Article
- A Hopeful Sea-Monster: A Very Large Homologous Recombination Event Impacting the Core Genome of the Marine PathogenFrontiers in microbiology · 2020Article
- Remarkable Genome Stability among emm1 Group A Streptococcus in Belgium over 19 Years.Genome biology and evolution · 2019Article
- Article
- Long-Term Intrahost Evolution of Methicillin ResistantFrontiers in genetics · 2019Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
The development of next-generation sequencing platforms is set to reveal an unprecedented level of detail on short-term molecular evolutionary processes in bacteria. Here we re-analyse genome-wide single nucleotide polymorphism (SNP) datasets for recently emerged clones of methicillin resistant Staphylococcus aureus (MRSA) and Clostridium difficile. We note a highly significant enrichment of synonymous SNPs in those genes which have been affected by recombination, i.e. those genes on mobile elements designated "non-core" (in the case of S. aureus), or those core genes which have been affected by homologous replacements (S. aureus and C. difficile). This observation suggests that the previously documented decrease in dN/dS over time in bacteria applies not only to genomes of differing levels of divergence overall, but also to horizontally acquired genes of differing levels of divergence within a single genome. We also consider the role of increased drift acting on recently emerged, highly specialised clones, and the impact of recombination on selection at linked sites. This work has implications for a wide range of genomic analyses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.