Trial reportObesity (Silver Spring, Md.)2011
Four-year weight losses in the Look AHEAD study: factors associated with long-term success.
Trial report in Obesity (Silver Spring, Md.), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04614545 (The Use of a Virtual Weight Management Program for Prescription of Phentermine in Patients With Overweight or Obesity Compared to Standard Face to Face Visits), which is not on this map. Cited by 240 papers, 11 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Use of a Virtual Weight Management Program for Prescription of Phentermine in Patients With Overweight or Obesity Compared to Standard Face to Face Visits
Who cites it
240 citing papers in PubMed, 11 syntheses or guidelines pooled it.
- A systematic review and meta-analysis of the efficacy and safety of pharmacological treatments for obesity in adults.Nature medicine · 2025 · on this mapPooled it
- A Systematic Review and Bayesian Network Meta-Analysis Comparing In-Person, Remote, and Blended Interventions in Physical Activity, Diet, Education, and Behavioral Modification on Gestational Weight Gain among Overweight or Obese Pregnant Individuals.Advances in nutrition (Bethesda, Md.) · 2024Pooled it
- Educational weight loss interventions in obese and overweight adults with type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials.Diabetic medicine : a journal of the British Diabetic Association · 2020Pooled it
- Determinants of weight loss maintenance: a systematic review.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2019Pooled it
- Effects of weight loss interventions for adults who are obese on mortality, cardiovascular disease, and cancer: systematic review and meta-analysis.BMJ (Clinical research ed.) · 2017Pooled it
- Diabetes Prevention Interventions in Latin American Countries: a Scoping Review.Current diabetes reports · 2016Pooled it
- A systematic review of motivational interviewing for weight loss among adults in primary care.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2015Pooled it
- Mobile phone intervention and weight loss among overweight and obese adults: a meta-analysis of randomized controlled trials.American journal of epidemiology · 2015Pooled it
- Effectiveness of weight loss interventions--is there a difference between men and women: a systematic review.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2015Pooled it
- 2013 AHA/ACC/TOS guideline for the management of overweight and obesity in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and The Obesity Society.Circulation · 2014 · on this mapGuideline
- Key elements of plant-based diets associated with reduced risk of metabolic syndrome.Current diabetes reports · 2014Pooled it
- Effects of a 2-Year Primary Care Weight Loss Intervention on Quality of Life in Patients With Obesity.Obesity (Silver Spring, Md.) · 2026Trial
- Long-term sustained effects of the Look AHEAD lifestyle intervention on body composition among adults with type 2 diabetes.Obesity (Silver Spring, Md.) · 2024Trial
- Psychological and Behavioral Predictors of Weight Loss in the Reach Ahead for Lifestyle and Health-Diabetes Lifestyle Intervention Cohort.Journal of the Academy of Nutrition and Dietetics · 2023Trial
- The use of virtual visits for obesity pharmacotherapy in patients with overweight or obesity compared with in-person encounters.Obesity (Silver Spring, Md.) · 2022Trial
- Results of a 2-year lifestyle intervention for type 2 diabetes: the Reach Ahead for Lifestyle and Health-Diabetes randomized controlled trial.Obesity (Silver Spring, Md.) · 2022Trial
- Outcome of lifestyle intervention in relation to duration of pre-diabetes: the Pathobiology and Reversibility of Prediabetes in a Biracial Cohort (PROP-ABC) study.BMJ open diabetes research & care · 2022Trial
- Patterns of weight change in a weight gain prevention study for young adults.Obesity (Silver Spring, Md.) · 2021Trial
- Trial
- Effects of a 2-Year Primary Care Lifestyle Intervention on Cardiometabolic Risk Factors: A Cluster-Randomized Trial.Circulation · 2021Trial
180 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
This report provides a further analysis of the year 4 weight losses in the Look AHEAD (Action for Health in Diabetes) study and identifies factors associated with long-term success. A total of 5,145 overweight/obese men and women with type 2 diabetes were randomly assigned to an intensive lifestyle intervention (ILI) or a usual care group, referred to as Diabetes Support and Education (DSE). ILI participants were provided approximately weekly group or individual treatment in year 1; continued but less frequent contact was provided in years 2-4. DSE participants received three group educational sessions in all years. As reported previously, at year 4, ILI participants lost an average of 4.7% of initial weight, compared with 1.1% for DSE (P < 0.0001). More ILI than DSE participants lost ≥ 5% (46% vs. 25%, P < 0.0001) and ≥ 10% (23% vs. 10%, P < 0.0001) of initial weight. Within the ILI, achievement of both the 5% and 10% categorical weight losses at year 4 was strongly related to meeting these goals at year 1. A total of 887 participants in ILI lost ≥ 10% at year 1, of whom 374 (42.2%) achieved this loss at year 4. Participants who maintained the loss, compared with those who did not, attended more treatment sessions and reported more favorable physical activity and food intake at year 4. These results provide critical evidence that a comprehensive lifestyle intervention can induce clinically significant weight loss (i.e., ≥ 5%) in overweight/obese participants with type 2 diabetes and maintain this loss in more than 45% of patients at 4 years.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.