Evidence map›Paper›PMID 21779028›Full record

ReviewNature reviews. Molecular cell biology2011

Molecular mechanism and physiological functions of clathrin-mediated endocytosis.

Harvey T McMahon, Emmanuel Boucrot

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Molecular cell biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1,125 papers.

0numbers the graph read from it
0cells of the map it votes in
1,125citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1,125 citing papers in PubMed.

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  19. Development of venus-fused Cypridina luciferase (VCL) and specific nanobody-tethering assay to model kleptoprotein uptake.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2026
    Article
  20. Review

1,065 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Harvey T McMahonMedical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK. hmm@mrc-lmb.cam.ac.uk
Emmanuel Boucrot

Funding

Medical Research Council MC_U105178795
6 · The paper itself

Abstract

Clathrin-mediated endocytosis is the endocytic portal into cells through which cargo is packaged into vesicles with the aid of a clathrin coat. It is fundamental to neurotransmission, signal transduction and the regulation of many plasma membrane activities and is thus essential to higher eukaryotic life. Morphological stages of vesicle formation are mirrored by progression through various protein modules (complexes). The process involves the formation of a putative FCH domain only (FCHO) initiation complex, which matures through adaptor protein 2 (AP2)-dependent cargo selection, and subsequent coat building, dynamin-mediated scission and finally auxilin- and heat shock cognate 70 (HSC70)-dependent uncoating. Some modules can be used in other pathways, and additions or substitutions confer cell specificity and adaptability.

Indexed as

ActinsAdaptor Protein Complex 2Adaptor Proteins, Vesicular TransportAnimalsClathrinClathrin-Coated VesiclesDynaminsEndocytosisHumansModels, BiologicalMutationNeoplasmsRNA InterferenceSignal TransductionSynaptic VesiclesActinsAdaptor Protein Complex 2Adaptor Proteins, Vesicular TransportClathrinDynamins

Identifiers

PMID21779028

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.