Evidence map›Paper›PMID 21779025›Full record

ReviewNature reviews. Molecular cell biology2011

Multisubunit RNA polymerases IV and V: purveyors of non-coding RNA for plant gene silencing.

Jeremy R Haag, Craig S Pikaard

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Molecular cell biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 228 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
228citing papers in PubMed, 1 pooled it
65.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

228 citing papers in PubMed, 1 synthesis or guideline pooled it, 402 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. DNA methylation in plant heterosis: mechanisms and prospects.Functional & integrative genomics · 2025
    Review
  7. DNA Methylation in Rice: Mechanisms, Regulatory Roles, and Beyond.International journal of molecular sciences · 2025
    Review
  8. Article
  9. Review
  10. Review
  11. Article
  12. Review
  13. Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article

168 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Jeremy R HaagDepartment of Biology, Indiana University, Bloomington, Indiana 47405, USA.
Craig S Pikaard
Indiana University Bloomington · US

Funding

Roles of RNA Polymerases IV and V in siRNA-mediated gene silencingR01GM077590 · NIGMS · WASHINGTON UNIVERSITY · PI PIKAARD, CRAIG STUART · 2006 to 2020
$3.5M
NIGMS NIH HHS GM077590NIGMS NIH HHS R01 GM077590
6 · The paper itself

Abstract

In all eukaryotes, nuclear DNA-dependent RNA polymerases I, II and III synthesize the myriad RNAs that are essential for life. Remarkably, plants have evolved two additional multisubunit RNA polymerases, RNA polymerases IV and V, which orchestrate non-coding RNA-mediated gene silencing processes affecting development, transposon taming, antiviral defence and allelic crosstalk. Biochemical details concerning the templates and products of RNA polymerases IV and V are lacking. However, their subunit compositions reveal that they evolved as specialized forms of RNA polymerase II, which provides the unique opportunity to study the functional diversification of a eukaryotic RNA polymerase family.

Indexed as

Amino Acid SequenceArabidopsisArabidopsis ProteinsDNA-Directed RNA PolymerasesDNA MethylationEvolution, MolecularGene SilencingModels, BiologicalMolecular Sequence DataProtein Structure, TertiaryProtein SubunitsRepetitive Sequences, Amino AcidRNA, PlantRNA, UntranslatedArabidopsis ProteinsDNA-Directed RNA PolymerasesProtein SubunitsRNA, PlantRNA polymerase IV, ArabidopsisRNA polymerase V, ArabidopsisRNA, Untranslated

Identifiers

PMID21779025
OpenAlexW2090042982

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.