Evidence map›Paper›PMID 21778743›Full record

ArticleHormone research in paediatrics2011

Novel strategies for improving physical function.

Shalender Bhasin, Ravi Jasuja, Powen Tu, Thomas W Storer, Wen Guo

Abstract readLecture
PubMed Full text at PMC Publisher
In one paragraph

Article in Hormone research in paediatrics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Shalender BhasinSection of Endocrinology, Diabetes and Nutrition, Boston University School of Medicine and Boston Medical Center, Boston, MA 02118, USA. bhasin@bu.edu
Ravi Jasuja
Powen Tu
Thomas W Storer
Wen Guo

Funding

Mechanism of Myostatin ActionR01DK078512 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI BHASIN, SHALENDER · 2009 to 2013
$3.2M
Mechanisms of Testosterone ActionR01AG037193 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI BHASIN, SHALENDER · 2010 to 2014
$2.2M
TESTOSTERONE REPLACEMENT &PHYSICAL FUNCTION IN HIV+MENR01DK049296 · NIDDK · LA BIOMED RES INST/ HARBOR UCLA MED CTR · PI BHASIN, SHALENDAR · 1994 to 2005
$1.7M
SARCOPENIA--TESTOSTERONE DOSE RESPONSE IN OLDER MENR01AG014369 · NIA · CHARLES R. DREW UNIVERSITY OF MED &SCI · PI BHASIN, SHALENDAR · 1997 to 2002
$839k
NIA NIH HHS R01 AG014369NIA NIH HHS R01 AG037193NIDDK NIH HHS R01 DK049296NIDDK NIH HHS R01 DK078512
6 · The paper itself

Abstract

backgroundThe number of elderly people is growing worldwide, and a substantial proportion of them report difficulty with mobility and in performing activities of daily living. The demographic trends have created enormous interest in development of function-promoting anabolic therapies. At present, androgens and myostatin inhibitors are the two leading classes of function-promoting anabolic therapies that are the most advanced in the drug development process. However, clinical development has been slowed by vexing trial design issues.

conclusionsClinical investigators, regulatory agencies and the National Institutes of Health must continue working toward a consensus about the indications for study, efficacy outcomes and what differences in functional outcomes are needed to determine sample size estimates.

Indexed as

AgedAged, 80 and overAgingAnabolic AgentsAndrogensAnimalsBody CompositionClinical Trials as TopicFemaleHumansMaleMuscle, SkeletalMyostatinTestosteroneAnabolic AgentsAndrogensMSTN protein, humanMyostatinTestosterone

Identifiers

PMID21778743
PMCPMC7065398

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.