ArticleAmerican journal of public health2011
"Speaking the dialect": understanding public discourse in the aftermath of an HIV vaccine trial shutdown.
Article in American journal of public health, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Stakeholder engagement to inform HIV clinical trials: a systematic review of the evidence.Journal of the International AIDS Society · 2018Pooled it
- Perception of potential harm and benefits of HIV vaccine trial participation: A qualitative study from urban Tanzania.PloS one · 2019Trial
- Gay and Bisexual Men's Perceptions about a Potential HIV Vaccine within a Post-COVID-19 Era: A Qualitative Study.AIDS and behavior · 2024Article
- Factors that impact on recruitment to vaccine trials in the context of a pandemic or epidemic: a qualitative evidence synthesis.The Cochrane database of systematic reviews · 2023Review
- Community engagement group model in basic and biomedical research: lessons learned from the BEAT-HIV Delaney Collaboratory towards an HIV-1 cure.Research involvement and engagement · 2023Article
- A qualitative study of COVID-19 vaccine decision making among urban Native Americans.Vaccine: X · 2022Article
- Exploring Perspectives on Establishing COVID-19 Vaccine Confidence in Black Communities.Ethnicity & disease · 2022Article
- COVID-19 Vaccine Decision-making Factors in Racial and Ethnic Minority Communities in Los Angeles, California.JAMA network open · 2021Article
- Re-examining the HIV 'functional cure' oxymoron: Time for precise terminology?Journal of virus eradication · 2020Article
- Applying the Behavioural and Social Sciences Research (BSSR) Functional Framework to HIV Cure Research.Journal of the International AIDS Society · 2019Review
- Acceptability of Cell and Gene Therapy for Curing HIV Infection Among People Living with HIV in the Northwestern United States: A Qualitative Study.AIDS research and human retroviruses · 2019Article
- 'Why would you promote something that is less percent safer than a condom?': Perspectives on partially effective HIV prevention technologies among key populations in South Africa.SAHARA J : journal of Social Aspects of HIV/AIDS Research Alliance · 2018Article
- If We Build It, Will They Come? Perceptions of HIV Cure-Related Research by People Living with HIV in Four U.S. Cities: A Qualitative Focus Group Study.AIDS research and human retroviruses · 2018Article
- Article
- Crowdsourcing and community engagement: a qualitative analysis of the 2BeatHIV contest.Journal of virus eradication · 2018Article
- Stakeholder Engagement in HIV Cure Research: Lessons Learned from Other HIV Interventions and the Way Forward.AIDS patient care and STDs · 2015Review
- Towards a Science of Community Stakeholder Engagement in Biomedical HIV Prevention Trials: An Embedded Four-Country Case Study.PloS one · 2015Article
- Drug users' willingness to encourage social, sexual, and drug network members to receive an HIV vaccine: a social network analysis.AIDS and behavior · 2014Article
- Legal and ethical values in the resolution of research-related disputes: how can IRBS respond to participant complaints?Journal of empirical research on human research ethics : JERHRE · 2014Article
- "If It's Not Working, Why Would They Be Testing It?": mental models of HIV vaccine trials and preventive misconception among men who have sex with men in India.BMC public health · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesWe investigated how persons from key populations at higher risk of HIV exposure interpreted the process and outcomes of the Step Study HIV-1 vaccine trial, which was terminated early, and implications for willingness to participate in and community support for HIV vaccine research.
methodsWe used qualitative methods and a community-based approach in 9 focus groups (n = 72) among ethnically and sexually diverse populations and 6 semistructured key informant interviews in Ontario, Canada, in 2007 to 2008.
resultsParticipants construed social meaning from complex clinical and biomedical phenomena. Social representations and mental models emerged in fears of vaccine-induced infection, conceptualizations of unfair recruitment practices and increased risk behaviors among trial participants, and questioning of informed consent. Narratives of altruism and the common good demonstrated support for future trials.
conclusionsPublic discourse on HIV vaccine trials is a productive means of interpreting complex clinical trial processes and outcomes in the context of existing beliefs and experiences regarding HIV vaccines, medical research, and historical disenfranchisement. Strategic engagement with social representations and mental models may promote meaningful community involvement in biomedical HIV prevention research.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.