ArticleJournal of applied physiology (Bethesda, Md. : 1985)2011
A continuum of myofibers in adult rabbit extraocular muscle: force, shortening velocity, and patterns of myosin heavy chain colocalization.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Multiterminal En Plaque Motor Endplates in Extraocular Muscles Are Conserved Across Vertebrate Species.Investigative ophthalmology & visual science · 2025Article
- One-Month-Old Rabbits Exhibit a Longer Postoperative Remodeling in Extraocular Muscles Compared to 3-Month-Old Rabbits.Investigative ophthalmology & visual science · 2025Article
- Effects of Short-Term Treatment of Rabbit Extraocular Muscle With Ciliary Neurotrophic Factor.Investigative ophthalmology & visual science · 2024Article
- Developmental, Physiological and Phylogenetic Perspectives on the Expression and Regulation of Myosin Heavy Chains in Craniofacial Muscles.International journal of molecular sciences · 2024Review
- Ion channel profiles of extraocular motoneurons and internuclear neurons in human abducens and trochlear nuclei.Frontiers in neuroanatomy · 2024Article
- Developmental, physiologic and phylogenetic perspectives on the expression and regulation of myosin heavy chains in mammalian skeletal muscles.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2023Review
- Myofiber Type Shift in Extraocular Muscles in Amyotrophic Lateral Sclerosis.Investigative ophthalmology & visual science · 2023Article
- Investigation of Selective Innervation of Extraocular Muscle Compartments.Investigative ophthalmology & visual science · 2023Article
- Morphological Differences in the Inferior Oblique Muscles from Subjects with Over-elevation in Adduction.Investigative ophthalmology & visual science · 2020Article
- Transitional Hybrid Skeletal Muscle Fibers in Rat Soleus Development.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2019Article
- Changing muscle function with sustained glial derived neurotrophic factor treatment of rabbit extraocular muscle.PloS one · 2018Article
- Extraocular Muscle Repair and Regeneration.Current ophthalmology reports · 2017Article
- Myosin Heavy Chain Expression Can Vary over the Length of Jaw and Leg Muscles.Cells, tissues, organs · 2016Article
- Sparing of the extraocular muscles in mdx mice with absent or reduced utrophin expression: A life span analysis.Neuromuscular disorders : NMD · 2015Article
- Adaptation of slow myofibers: the effect of sustained BDNF treatment of extraocular muscles in infant nonhuman primates.Investigative ophthalmology & visual science · 2015Article
- Adaptability of the Immature Ocular Motor Control System: Unilateral IGF-1 Medial Rectus Treatment.Investigative ophthalmology & visual science · 2015Article
- Abnormal activity of neurons in abducens nucleus of strabismic monkeys.Investigative ophthalmology & visual science · 2014Article
- Magnetic resonance imaging of differential compartmental function of horizontal rectus extraocular muscles during conjugate and converged ocular adduction.Journal of neurophysiology · 2014Article
- Wnt and extraocular muscle sparing in amyotrophic lateral sclerosis.Investigative ophthalmology & visual science · 2014Article
- Complex tropomyosin and troponin T isoform expression patterns in orbital and global fibers of adult dog and rat extraocular muscles.Journal of muscle research and cell motility · 2013Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Extraocular muscle (EOM) myofibers do not fit the traditional fiber typing classifications normally used in noncranial skeletal muscle, in part, due to the complexity of their individual myofibers. With single skinned myofibers isolated from rectus muscles of normal adult rabbits, force and shortening velocity were determined for 220 fibers. Each fiber was examined for myosin heavy chain (MyHC) isoform composition by densitometric analysis of electrophoresis gels. Rectus muscle serial sections were examined for coexpression of eight MyHC isoforms. A continuum was seen in single myofiber shortening velocities as well as force generation, both in absolute force (g) and specific tension (kN/m(2)). Shortening velocity correlated with MyHCIIB, IIA, and I content, the more abundant MyHC isoforms expressed within individual myofibers. Importantly, single fibers with similar or identical shortening velocities expressed significantly different ratios of MyHC isoforms. The vast majority of myofibers in both the orbital and global layers expressed more than one MyHC isoform, with up to six isoforms in single fiber segments. MyHC expression varied significantly and unpredictably along the length of single myofibers. Thus EOM myofibers represent a continuum in their histological and physiological characteristics. This continuum would facilitate fine motor control of eye position, speed, and direction of movement in all positions of gaze and with all types of eye movements-from slow vergence movements to fast saccades. To fully understand how the brain controls eye position and movements, it is critical that this significant EOM myofiber heterogeneity be integrated into hypotheses of oculomotor control.
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