Trial reportChest2011
The effect of weight loss and exercise training on flow-mediated dilatation in coronary heart disease: a randomized trial.
Trial report in Chest, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Methods of Weight Loss in Overweight Coronary Patients
Single-centre, Single-blind, Randomized, Controlled, Cross-over Study to Analyze the Influence of Nitric Oxide on Flow Mediated Dilation
Who cites it
22 citing papers in PubMed, 51 citations in OpenAlex.
- Effect of Wearable Devices and 5G-Powered Remote Precision Rehabilitation on Vascular Function in Post-PCI Patients: An Analysis of the Associations Between FMS, Cardiorespiratory Fitness, and Arterial Stiffness.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Trial
- The effect of physical activity on cardiometabolic health and inflammation in treated HIV infection.Antiviral therapy · 2016Trial
- Endothelial function is well preserved in obese patients with mild obstructive sleep apnea.Sleep & breathing = Schlaf & Atmung · 2014Trial
- Effects of aerobic training on brachial artery flow-mediated dilation in healthy adults: a meta-analysis of inter-individual response differences in randomized controlled trials.BMC sports science, medicine & rehabilitation · 2025Article
- Potential preservative mechanisms of cardiac rehabilitation pathways on endothelial function in coronary heart disease.Science China. Life sciences · 2025Review
- Ischemia with Nonobstructive Coronary Artery Disease and Atrial Cardiomyopathy-Two Sides of the Same Story?Life (Basel, Switzerland) · 2023Review
- The Treatment of Obesity in Cardiac Rehabilitation: A REVIEW AND PRACTICAL RECOMMENDATIONS.Journal of cardiopulmonary rehabilitation and prevention · 2021Review
- Effects of a rehabilitation program on microvascular function of CHD patients assessed by near-infrared spectroscopy.Physiological reports · 2019Article
- Effects of Catheterization on Artery Function and Health: When Should Patients Start Exercising Following Their Coronary Intervention?Sports medicine (Auckland, N.Z.) · 2019Review
- Effect of Exercise Intervention on Flow-Mediated Dilation in Overweight and Obese Adults: Meta-Analysis.International journal of vascular medicine · 2017Review
- Consequences of obesity and weight loss: a devil's advocate position.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2015Review
- Time-course of vascular adaptations during 8 weeks of exercise training in subjects with type 2 diabetes and middle-aged controls.European journal of applied physiology · 2015Article
- How should we advise heart failure patients on exercise and what should we tell them?Current heart failure reports · 2014Review
- Effects of moderate aerobic exercise training on vascular health and blood pressure in African Americans.Journal of clinical hypertension (Greenwich, Conn.) · 2014Article
- Walking disability in patients with peripheral artery disease is associated with arterial endothelial function.Journal of vascular surgery · 2014Article
- Endothelial function increases after a 16-week diet and exercise intervention in overweight and obese young women.BioMed research international · 2014Article
- Life-long aerobic exercise preserved baseline cerebral blood flow but reduced vascular reactivity to CO2.Journal of magnetic resonance imaging : JMRI · 2013Article
- Does brachial artery flow-mediated vasodilation provide a bioassay for NO?Hypertension (Dallas, Tex. : 1979) · 2013Article
- Shorter term aerobic exercise improves brain, cognition, and cardiovascular fitness in aging.Frontiers in aging neuroscience · 2013Article
- Endothelial dysfunction in diabetes: pathogenesis, significance, and treatment.The review of diabetic studies : RDSReview
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
backgroundMore than 80% of patients entering cardiac rehabilitation are overweight, with a high prevalence of associated insulin resistance, diabetes, hypertension, hyperlipidemia, and a prothrombotic state. Because each of these characteristics is associated with abnormalities of endothelial-dependent flow-mediated dilatation (FMD), a predictor of long-term prognosis in patients with coronary heart disease (CHD), we assessed the effect of exercise training and weight reduction on FMD in overweight patients with CHD.
methodsAll patients (N = 38) participated in behavioral weight loss while taking their usual preventive medications. Subjects were randomized to one of two exercise protocols, which differed by caloric expenditure. The primary outcome was extent (%) of brachial artery FMD measured by ultrasonography before and after the 4-month exercise and weight-loss program.
resultsBoth study groups experienced an increase in brachial artery FMD after weight loss and exercise. Patients randomized to the higher-caloric exercise condition (longer-distance walking) lost more weight (8.6 ± 4.1 kg vs 2.3 ± 3.3 kg [P < .001]) and experienced a greater percentage increase in brachial artery FMD (3.6% ± 4.1% vs 1.3% ± 2.1%, P < .05) than did subjects in the lower-caloric-expenditure exercise group who lost less weight. Both groups increased peak aerobic capacity similarly. Increased FMD correlated with changes in body weight more than with measures of abdominal fat, glucose disposal, lipid measure, BP, or measures of physical activity or cardiorespiratory fitness.
conclusionsExercise and weight loss increased FMD in overweight and obese patients with CHD. Greater weight reduction was associated with a greater improvement in FMD; thus, there was a dose effect. TRIAL REGISTRY: ClinicalTrials.gov; No.: NCT00628277; URL: www.clinicaltrials.gov.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.