ArticleThe Journal of clinical endocrinology and metabolism2011
Adiposity and hot flashes in midlife women: a modifying role of age.
Article in The Journal of clinical endocrinology and metabolism, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Guideline
- Oral micronized progesterone for perimenopausal night sweats and hot flushes a Phase III Canada-wide randomized placebo-controlled 4 month trial.Scientific reports · 2023Trial
- Cardiometabolic measures and cognition in early menopause - Analysis of baseline data from a randomized controlled trial.Maturitas · 2022Trial
- Effects of estrogen and venlafaxine on menopause-related quality of life in healthy postmenopausal women with hot flashes: a placebo-controlled randomized trial.Menopause (New York, N.Y.) · 2015Trial
- Behavioral weight loss for the management of menopausal hot flashes: a pilot study.Menopause (New York, N.Y.) · 2015Trial
- Obesity and female reproductive health in Asian population.Obesity pillars · 2026Review
- Bothersome symptoms at midlife in relation to body fat percentage.American journal of human biology : the official journal of the Human Biology Council · 2024Article
- [Preventive activities in women. PAPPS update 2022].Atencion primaria · 2022Article
- Association of depression, anxiety and menopausal-related symptoms with demographic, anthropometric and body composition indices in healthy postmenopausal women.BMC women's health · 2021Article
- Genetic variants predictive of reproductive aging are associated with vasomotor symptoms in a multiracial/ethnic cohort.Menopause (New York, N.Y.) · 2021Article
- [Preventive activities in women's care].Atencion primaria · 2020Article
- Association of hot flushes with ghrelin and adipokines in early versus late postmenopausal women.Menopause (New York, N.Y.) · 2020Article
- Vasomotor Symptoms and Accelerated Epigenetic Aging in the Women's Health Initiative (WHI).The Journal of clinical endocrinology and metabolism · 2020 · on this mapObservational
- Hot flashes and awakenings among midlife women.Sleep · 2019Article
- Association of Mid-Life Changes in Body Size, Body Composition and Obesity Status with the Menopausal Transition.Healthcare (Basel, Switzerland) · 2016Review
- Bladder Symptoms in the Early Menopausal Transition.Journal of women's health (2002) · 2016Article
- Perimenopause as a neurological transition state.Nature reviews. Endocrinology · 2015Review
- Change in body mass index, weight, and hot flashes: a longitudinal analysis from the midlife women's health study.Journal of women's health (2002) · 2014Article
- How well do different measurement modalities estimate the number of vasomotor symptoms? Findings from the Study of Women's Health Across the Nation FLASHES Study.Menopause (New York, N.Y.) · 2014Article
- Hot flashes are not predictive for serum concentrations of tamoxifen and its metabolites.BMC cancer · 2013Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe nature of the relationship between adiposity and hot flashes has been debated, but it has not been examined using physiological measures of hot flashes. We examined associations between body size/composition and physiologically assessed hot flashes among women with hot flashes.
methodsA subcohort of women in the Study of Women's Health Across the Nation (n = 52; 25 African-American and 27 non-Hispanic Caucasian; ages, 54 to 63 yr) who reported hot flashes, had their uterus and ovaries, and were not taking medications impacting hot flashes were recruited in 2008-2009. Women completed anthropometric measures [bioimpedance analysis of total percentage of body fat, body mass index (BMI), waist circumference], a blood draw (estradiol, SHBG, FSH, dehydroepiandrosterone sulfate), and 4 d of ambulatory sternal skin conductance monitoring with diary (physiological and reported hot flashes, respectively). Associations between anthropometrics and hot flashes were estimated with generalized estimating equations with covariates age, race, and anxiety.
resultsHigher BMI (odds ratio, 0.97; 95% confidence interval, 0.94-0.99; P < 0.05) and waist circumference (odds ratio, 0.98; 95% confidence interval, 0.97-0.99; P < 0.01) were associated with fewer physiological hot flashes. Interactions by age (P < 0.05) indicated that inverse associations of body fat, BMI, and waist circumference with hot flashes were most apparent among the oldest women in the sample. Estradiol and SHBG reduced but did not eliminate age-related variations in relations between body size/composition and hot flashes.
conclusionHigher adiposity was associated with fewer physiological hot flashes among older women with hot flashes. A modifying role of age must be considered in understanding the role of adiposity in hot flashes.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.