Evidence map›Paper›PMID 21778142›Full record

ArticleBiology of reproduction2011

Voltage-gated potassium currents are targets of diurnal changes in estradiol feedback regulation and kisspeptin action on gonadotropin-releasing hormone neurons in mice.

Justyna Pielecka-Fortuna, R Anthony DeFazio, Suzanne M Moenter

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biology of reproduction, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
3.3field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 38 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Modelling KNDy neurons and gonadotropin-releasing hormone pulse generation.Current opinion in endocrine and metabolic research · 2022
    Review
  6. Review
  7. Article
  8. Role of potassium channels in female reproductive system.Obstetrics & gynecology science · 2020
    Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Gonadotropin-Releasing Hormone (GnRH) Neuron Excitability Is Regulated by Estradiol Feedback and Kisspeptin.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018
    Article
  15. Article
  16. A unified model for two modes of bursting in GnRH neurons.Journal of computational neuroscience · 2016
    Article
  17. Review
  18. Article
  19. Kisspeptin excitation of GnRH neurons.Advances in experimental medicine and biology · 2013
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Justyna Pielecka-FortunaNeuroscience Graduate Program, University of Virginia, Charlottesville, Virginia, USA.
R Anthony DeFazio
Suzanne M Moenter
University of Miami · USUniversity of Michigan–Ann Arbor · USUniversity of Virginia · US

Funding

Central Actions of Estrogens: Effects on GnRH NeuronsR01HD041469 · NICHD · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Suzanne M MOENTER · 2002 to 2026
$8.8M
NICHD NIH HHS R01 HD041469NICHD NIH HHS R01 HD41469
6 · The paper itself

Abstract

Estradiol has both negative and positive feedback actions upon gonadotropin-releasing hormone (GnRH) release; the latter actions trigger the preovulatory GnRH surge. Although neurobiological mechanisms of the transitions between feedback modes are becoming better understood, the roles of voltage-gated potassium currents, major contributors to neuronal excitability, are unknown. Estradiol alters two components of potassium currents in these cells: a transient current, I(A), and a sustained current, I(K). Kisspeptin is a potential mediator between estradiol and GnRH neurons and can act directly on GnRH neurons. We examined how estradiol, time of day, and kisspeptin interact to regulate these conductances in a mouse model exhibiting daily switches between estradiol negative (morning) and positive feedback (evening). Whole-cell voltage clamp recordings were made from GnRH neurons in brain slices from ovariectomized (OVX) mice and from OVX mice treated with estradiol (OVX+E). There were no diurnal changes in either I(A) or I(K) in GnRH neurons from OVX mice. In contrast, in GnRH neurons from OVX+E mice, I(A) and I(K) were greater during the morning when GnRH neuron activity is low and smaller in the evening when GnRH neuron activity is high. Estradiol increased I(A) in the morning and decreased it in the evening, relative to that in cells from OVX mice. Exogenously applied kisspeptin reduced I(A) regardless of time of day or estradiol status. Estradiol, interacting with time of day, and kisspeptin both depolarized I(A) activation. These findings extend our understanding of both the neurobiological mechanisms of estradiol negative vs. positive regulation of GnRH neurons and of kisspeptin action on these cells.

Indexed as

AnimalsBrainCircadian RhythmEstradiolFeedback, PhysiologicalFemaleGonadotropin-Releasing HormoneGreen Fluorescent ProteinsKisspeptinsMiceMice, TransgenicModels, AnimalNeuronsOvariectomyPatch-Clamp TechniquesPotassium Channels, Voltage-GatedEstradiolGonadotropin-Releasing HormoneGreen Fluorescent ProteinsKisspeptinsPotassium Channels, Voltage-Gated

Identifiers

PMID21778142
PMCPMC3197916
OpenAlexW2049995245

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.