ArticleMechanisms of ageing and development2011
Localised micro-mechanical stiffening in the ageing aorta.
Article in Mechanisms of ageing and development, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 56 citations in OpenAlex.
- Biomechanical changes after repeated collagen cross-linking on human corneas assessed in vitro using scanning acoustic microscopy.Investigative ophthalmology & visual science · 2014Trial
- Dissection Propagation via Avalanches in Human Descending Thoracic Aorta: Effect of Aging.Acta biomaterialia · 2025Article
- Unraveling Elastic Fiber-Derived Signaling in Arterial Aging and Related Arterial Diseases.Biomolecules · 2025Review
- Biomechanical effects of hemin and sildenafil treatments on the aortic wall of chronic-hypoxic lambs.Frontiers in bioengineering and biotechnology · 2024Article
- Macro- and micromechanical remodelling in the fish atrium is associated with regulation of collagen 1 alpha 3 chain expression.Pflugers Archiv : European journal of physiology · 2018Article
- AFM Characterization of the Internal Mammary Artery as a Novel Target for Arterial Stiffening.Scanning · 2018Article
- Ultrahigh-Resolution Optical Coherence Elastography Images Cellular-Scale Stiffness of Mouse Aorta.Biophysical journal · 2017Article
- TGF-β1 in Vascular Wall Pathology: Unraveling Chronic Venous Insufficiency Pathophysiology.International journal of molecular sciences · 2017Review
- Frequency-modulated atomic force microscopy localises viscoelastic remodelling in the ageing sheep aorta.Journal of the mechanical behavior of biomedical materials · 2016Article
- Cardiovascular function, compliance, and connective tissue remodeling in the turtle, Trachemys scripta, following thermal acclimation.American journal of physiology. Regulatory, integrative and comparative physiology · 2016Article
- A pilot study of scanning acoustic microscopy as a tool for measuring arterial stiffness in aortic biopsies.Artery research · 2016Article
- Increased peri-ductal collagen micro-organization may contribute to raised mammographic density.Breast cancer research : BCR · 2016Article
- Morphological Characterisation of Unstained and Intact Tissue Micro-architecture by X-ray Computed Micro- and Nano-Tomography.Scientific reports · 2015Article
- Efficient and optimized identification of generalized Maxwell viscoelastic relaxation spectra.Journal of the mechanical behavior of biomedical materials · 2015Article
- The Dynamic Nature of Hypertrophic and Fibrotic Remodeling of the Fish Ventricle.Frontiers in physiology · 2015Article
- Localized micro- and nano-scale remodelling in the diabetic aorta.Acta biomaterialia · 2014Article
- Age-related remodeling of small arteries is accompanied by increased sphingomyelinase activity and accumulation of long-chain ceramides.Physiological reports · 2014Article
- Growth differentiation factor 6 and transforming growth factor-beta differentially mediate mesenchymal stem cell differentiation, composition, and micromechanical properties of nucleus pulposus constructs.Arthritis research & therapy · 2014Article
- LOXL4 is induced by transforming growth factor β1 through Smad and JunB/Fra2 and contributes to vascular matrix remodeling.Molecular and cellular biology · 2013Article
- Age-Related Tissue Stiffening: Cause and Effect.Advances in wound care · 2013Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Age-related loss of tissue elasticity is a common cause of human morbidity and arteriosclerosis (vascular stiffening) is associated with the development of both fatal strokes and heart failure. However, in the absence of appropriate micro-mechanical testing methodologies, multiple structural remodelling events have been proposed as the cause of arteriosclerosis. Therefore, using a model of ageing in female sheep aorta (young: <18 months, old: >8 years) we: (i) quantified age-related macro-mechanical stiffness, (ii) localised in situ micro-metre scale changes in acoustic wave speed (a measure of tissue stiffness) and (iii) characterised collagen and elastic fibre remodelling. With age, there was an increase in both macro-mechanical stiffness and mean microscopic wave speed (and hence stiffness; young wave speed: 1701±1ms(-1), old wave speed: 1710±1ms(-1), p<0.001) which was localized to collagen fibril-rich regions located between large elastic lamellae. These micro-mechanical changes were associated with increases in both collagen and elastic fibre content (collagen tissue area, young: 31±2%, old: 40±4%, p<0.05; elastic fibre tissue area, young: 55±3%, old: 69±4%, p<0.001). Localised collagen fibrosis may therefore play a key role in mediating age-related arteriosclerosis. Furthermore, high frequency scanning acoustic microscopy is capable of co-localising micro-mechanical and micro-structural changes in ageing tissues.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.