ArticleThe American journal of pathology2011
Chronic wasting disease prion trafficking via the autonomic nervous system.
Article in The American journal of pathology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 30 citations in OpenAlex.
- Extraneural infection route restricts prion conformational variability and attenuates the impact of quaternary structure on infectivity.PLoS pathogens · 2024Article
- RT-QuIC detection of chronic wasting disease prion in platelet samples of white-tailed deer.BMC veterinary research · 2024Article
- Enteric glia as friends and foes of the intestinal epithelial barrier function.Frontiers in immunology · 2024Article
- Potential roles of enteric glial cells in Crohn's disease: A critical review.Cell proliferation · 2024Review
- New developments in prion disease research using genetically modified mouse models.Cell and tissue research · 2023Review
- Enteric glial biology, intercellular signalling and roles in gastrointestinal disease.Nature reviews. Gastroenterology & hepatology · 2021Review
- The ecology of chronic wasting disease in wildlife.Biological reviews of the Cambridge Philosophical Society · 2020Review
- Article
- Assessment of Chronic Wasting Disease Prion Shedding in Deer Saliva with Occupancy Modeling.Journal of clinical microbiology · 2018Article
- Evolution of Diagnostic Tests for Chronic Wasting Disease, a Naturally Occurring Prion Disease of Cervids.Pathogens (Basel, Switzerland) · 2017Review
- Article
- Enteric Glial Cells: A New Frontier in Neurogastroenterology and Clinical Target for Inflammatory Bowel Diseases.Inflammatory bowel diseases · 2016Review
- Emerging roles for enteric glia in gastrointestinal disorders.The Journal of clinical investigation · 2015Review
- Mucosal immunization with an attenuated Salmonella vaccine partially protects white-tailed deer from chronic wasting disease.Vaccine · 2015Article
- Lesion profiling and subcellular prion localization of cervid chronic wasting disease in domestic cats.Veterinary pathology · 2015Article
- Susceptibility of domestic cats to chronic wasting disease.Journal of virology · 2013Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Chronic wasting disease (CWD) is a fatal spongiform encephalopathy that is efficiently transmitted among members of the mammalian family Cervidae, including deer, elk, and moose. Typical of prion diseases, CWD is characterized by the conversion of the native protease-sensitive protein PrP(C) to a protease-resistant isoform, denoted PrP(RES). In native species, spread of the disease likely results from the ingestion of prion-containing excreta, including urine, saliva, or feces. Although cervid prion protein-expressing transgenic [Tg(CerPrP)] mice have been shown to be effective surrogates of natural CWD, uncertainties remain regarding the mechanisms by which CWD prions traffic in vivo, including the manner by which CWD prions traffic from the gastrointestinal tract to the central nervous system. We used elk prion protein-expressing transgenic [Tg(CerPrP-E)] mice, infected by three different routes of inoculation, and tissue-based IHC to elucidate that centripetal and centrifugal CWD prion transit pathways involve cells and fibers of the autonomic nervous systems, including the enteric nervous system and central autonomic network. Moreover, we identified CWD PrP(RES) associated with the cell bodies and processes of enteric glial cells within the enteric nervous system of CWD-infected Tg(CerPrP-E) mice. The present findings demonstrate the importance of the peripheral and central autonomic networks in CWD neuroinvasion and neuropathogenesis and suggest that enteroglial cells may facilitate the shedding of prions via the intestinal tract.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.