ArticleJournal of clinical microbiology1990
Characterization of the sequence of colonization and nosocomial candidemia using DNA fingerprinting and a DNA probe.
Article in Journal of clinical microbiology, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
58 citing papers in PubMed, 218 citations in OpenAlex.
- Oral nystatin prophylaxis to prevent systemic fungal infection in very low birth weight preterm infants: a randomized controlled trial.BMC pediatrics · 2020Trial
- Prevalence, Species Distribution and Resistance of Candidemia in Pediatric and Adult Patients in a Northeast Italy University Hospital.Journal of fungi (Basel, Switzerland) · 2024Article
- The Gastrointestinal Tract Is Pinpointed as a Reservoir ofJournal of fungi (Basel, Switzerland) · 2023Article
- The Role of Host and Fungal Factors in the Commensal-to-Pathogen Transition ofCurrent clinical microbiology reports · 2023Review
- Risk factors for candidemia: a prospective matched case-control study.Critical care (London, England) · 2020Article
- Commensal Candida albicans Positively Calibrates Systemic Th17 Immunological Responses.Cell host & microbe · 2019Article
- Candida albicans-Induced Epithelial Damage Mediates Translocation through Intestinal Barriers.mBio · 2018Article
- Multi-Locus Next-Generation Sequence Typing of DNA Extracted From Pooled Colonies Detects Multiple UnrelatedFrontiers in microbiology · 2018Article
- Distribution and antifungal susceptibility of yeasts isolates from intensive care unit patients.Folia microbiologica · 2017Article
- Article
- Evaluation of Polymorphic Locus Sequence Typing for Candida glabrata Epidemiology.Journal of clinical microbiology · 2016Article
- Mechanisms of echinocandin antifungal drug resistance.Annals of the New York Academy of Sciences · 2015Review
- Article
- Echinocandin resistance, susceptibility testing and prophylaxis: implications for patient management.Drugs · 2014Review
- Candida glabrata: a review of its features and resistance.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2014Review
- National surveillance of fungemia in Denmark (2004 to 2009).Journal of clinical microbiology · 2011Article
- Canadian clinical practice guidelines for invasive candidiasis in adults.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2010Article
- Noninvasive ventilation for patients near the end of life: what do we know and what do we need to know?Critical care medicine · 2008Article
- Candida albicans strain maintenance, replacement, and microvariation demonstrated by multilocus sequence typing.Journal of clinical microbiology · 2006Article
- Molecular epidemiology of long-term colonization of Candida albicans strains from HIV-infected patients.Epidemiology and infection · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The objective of this hospital-based study was to determine the relationship between colonizing and infecting strains of Candida species and Torulopsis glabrata. Surveillance cultures from high-risk patients were paired with subsequent bloodstream isolates. Organisms were typed by using restriction endonuclease digestion of chromosomal DNA with BstNI and EcoRI, followed by Southern hybridization with a DNA probe (pBD4) derived from Saccharomyces cerevisiae. Sixteen patients for whom documented colonization preceded documented bloodstream infection were identified. The mean time between obtainment of surveillance isolates and obtainment of bloodstream isolates was 8 days, with a range of 1 to 423 days. For 15 (94%) of 16 patients, the DNA fingerprint pattern (using BstNI) of the surveillance isolate was identical to that of the bloodstream isolate. Isolates from 13 (81%) of 16 patients were unique to those patients. Typing by Southern hybridization with the pBD4 probe was less discriminating. We conclude that for a well-defined subset of hospitalized patients who were colonized by Candida species before developing nosocomial candidemia, the colonizing and infecting strains were identical, suggesting endogenous acquisition of infection. Restriction endonuclease digestion of chromosomal DNA was shown to be a discriminating and reproducible typing method for Candida species and T. glabrata.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.