Evidence map›Paper›PMID 21777476›Full record

ArticleChinese medicine2011

Anti-cancer natural products isolated from chinese medicinal herbs.

Wen Tan, Jinjian Lu, Mingqing Huang, Yingbo Li, Meiwan Chen, Guosheng Wu, Jian Gong, Zhangfeng Zhong, Zengtao Xu, Yuanye Dang and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chinese medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 131 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
131citing papers in PubMed, 1 pooled it
14.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

131 citing papers in PubMed, 1 synthesis or guideline pooled it, 395 citations in OpenAlex.

  1. Pooled it
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  20. [Myrislignan Induces Apoptosis in Gastric Cancer Cell Line Through PI3K/AKT Signaling Pathway].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2023
    Article

71 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 2 countries.

Wen Tan *State Key Laboratory of Quality Research in Chinese Medicine, University of Macau, Av. Padre Toma's Pereira S.J., Taipa, Macao SAR, China.
Jinjian Lu *State Key Laboratory of Quality Research in Chinese Medicine, University of Macau, Av. Padre Toma's Pereira S.J., Taipa, Macao SAR, China.
Mingqing HuangState Key Laboratory of Quality Research in Chinese Medicine, University of Macau, Av. Padre Toma's Pereira S.J., Taipa, Macao SAR, China.
Yingbo LiState Key Laboratory of Quality Research in Chinese Medicine, University of Macau, Av. Padre Toma's Pereira S.J., Taipa, Macao SAR, China.
Meiwan ChenState Key Laboratory of Quality Research in Chinese Medicine, University of Macau, Av. Padre Toma's Pereira S.J., Taipa, Macao SAR, China.
Guosheng WuState Key Laboratory of Quality Research in Chinese Medicine, University of Macau, Av. Padre Toma's Pereira S.J., Taipa, Macao SAR, China.
Jian GongState Key Laboratory of Quality Research in Chinese Medicine, University of Macau, Av. Padre Toma's Pereira S.J., Taipa, Macao SAR, China.
Zhangfeng ZhongState Key Laboratory of Quality Research in Chinese Medicine, University of Macau, Av. Padre Toma's Pereira S.J., Taipa, Macao SAR, China.
Zengtao XuState Key Laboratory of Quality Research in Chinese Medicine, University of Macau, Av. Padre Toma's Pereira S.J., Taipa, Macao SAR, China.
Yuanye DangState Key Laboratory of Quality Research in Chinese Medicine, University of Macau, Av. Padre Toma's Pereira S.J., Taipa, Macao SAR, China.
Jiajie GuoState Key Laboratory of Quality Research in Chinese Medicine, University of Macau, Av. Padre Toma's Pereira S.J., Taipa, Macao SAR, China.
Xiuping ChenState Key Laboratory of Quality Research in Chinese Medicine, University of Macau, Av. Padre Toma's Pereira S.J., Taipa, Macao SAR, China.
Yitao WangState Key Laboratory of Quality Research in Chinese Medicine, University of Macau, Av. Padre Toma's Pereira S.J., Taipa, Macao SAR, China.
University of Macau · MO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In recent years, a number of natural products isolated from Chinese herbs have been found to inhibit proliferation, induce apoptosis, suppress angiogenesis, retard metastasis and enhance chemotherapy, exhibiting anti-cancer potential both in vitro and in vivo. This article summarizes recent advances in in vitro and in vivo research on the anti-cancer effects and related mechanisms of some promising natural products. These natural products are also reviewed for their therapeutic potentials, including flavonoids (gambogic acid, curcumin, wogonin and silibinin), alkaloids (berberine), terpenes (artemisinin, β-elemene, oridonin, triptolide, and ursolic acid), quinones (shikonin and emodin) and saponins (ginsenoside Rg3), which are isolated from Chinese medicinal herbs. In particular, the discovery of the new use of artemisinin derivatives as excellent anti-cancer drugs is also reviewed.

Identifiers

PMID21777476
PMCPMC3149025
OpenAlexW2142518692

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.