ArticleSocial neuroscience2011
Neural correlates of social approach and withdrawal in patients with major depression.
Article in Social neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 3 of them syntheses that pooled it.
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Who cites it
45 citing papers in PubMed, 3 syntheses or guidelines pooled it, 97 citations in OpenAlex.
- The conscious processing of emotion in depression disorder: a meta-analysis of neuroimaging studies.Frontiers in psychiatry · 2023Pooled it
- Abnormal neural activities in adults and youths with major depressive disorder during emotional processing: a meta-analysis.Brain imaging and behavior · 2021Pooled it
- Mapping anhedonia-specific dysfunction in a transdiagnostic approach: an ALE meta-analysis.Brain imaging and behavior · 2016Pooled it
- Smartphone-Based Approach-Avoidance Bias Modification Training for Depression: Randomized Clinical Trial.JMIR mHealth and uHealth · 2025Trial
- A multi-site proof-of-concept investigation of computerized approach-avoidance training in adolescent cannabis users.Drug and alcohol dependence · 2018Trial
- Emotion-Processing Biases and Neural Connectivity in Remitted Major Depressive Disorder among Adolescents.Clinical psychological science : a journal of the Association for Psychological Science · 2026Article
- Religious Service Attendance, Religious Discrimination, and Well-being in a Nationally Representative Sample of Canadians.Journal of religion and health · 2025Article
- Reduced neural activation during positive social approach is associated with better response to approach avoidance training for social anxiety disorder.Journal of mood and anxiety disorders · 2025Article
- Non-verbal effecting - animal research sheds light on human emotion communication.Biological reviews of the Cambridge Philosophical Society · 2025Review
- Exploring automatic approach-avoidance tendencies: the impact of self-relevant social feedback on behavior.Frontiers in psychology · 2025Article
- Bidirectional Relationships Between Hours Worked and Social Anxiety and Depression Symptoms: A Longitudinal Study.Psychiatric research and clinical practice · 2025Article
- A pull to be close: The differentiating effects of oxytocin and grief stimulus type on approach behavior in complicated grief.European journal of trauma & dissociation = Revue europeenne du trauma et de la dissociation · 2023Article
- Effects of binge drinking and depression on cognitive-control processes during an emotional Go/No-Go task in emerging adults.Journal of psychiatric research · 2023Article
- Behavioural approach-avoidance tendencies among individuals with elevated blood pressure.Current psychology (New Brunswick, N.J.) · 2023Article
- Social avoidance behavior modulates motivational responses to social reward-threat conflict signals: A preliminary fMRI study.Cognitive, affective & behavioral neuroscience · 2023Article
- Differential Orbitofrontal Cortex Responses to Chocolate Images While Performing an Approach-Avoidance Task in the MRI Environment.Nutrients · 2023Article
- Avoidance Bias to Angry Faces Predicts the Development of Depressive Symptoms among Adolescent Girls.Research on child and adolescent psychopathology · 2022Article
- Positive and negative experiences with the COVID-19 pandemic among lonely and non-lonely populations in Germany.Frontiers in public health · 2022Article
- Encore: Behavioural animal models of stress, depression and mood disorders.Frontiers in behavioral neuroscience · 2022Review
- Neural Changes in Reward Processing Following Approach Avoidance Training for Depression.Social cognitive and affective neuroscience · 2021Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 3 countries.
Funding
Abstract
Successful human interaction is based on correct recognition, interpretation, and appropriate reaction to facial affect. In depression, social skill deficits are among the most restraining symptoms leading to social withdrawal, thereby aggravating social isolation and depressive affect. Dysfunctional approach and withdrawal tendencies to emotional stimuli have been documented, but the investigation of their neural underpinnings has received limited attention. We performed an fMRI study including 15 depressive patients and 15 matched, healthy controls. All subjects performed two tasks, an implicit joystick task as well as an explicit rating task, both using happy, neutral, and angry facial expressions. Behavioral data analysis indicated a significant group effect, with depressed patients showing more withdrawal than controls. Analysis of the functional data revealed significant group effects for both tasks. Among other regions, we observed significant group differences in amygdala activation, with patients showing less response particularly during approach to happy faces. Additionally, significant correlations of amygdala activation with psychopathology emerged, suggesting that more pronounced symptoms are accompanied by stronger decreases of amygdala activation. Hence, our results demonstrate that depressed patients show dysfunctional social approach and withdrawal behavior, which in turn may aggravate the disorder by negative social interactions contributing to isolation and reinforcing cognitive biases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.