ArticleSmall GTPases2011
Distinct yet overlapping roles of Rab GTPases on synaptic vesicles.
Article in Small GTPases, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
42 citing papers in PubMed, 86 citations in OpenAlex.
- Genetic subtraction reveals divergent pathways and targets in anxiety-related and anxiety-independent TMD.The journal of headache and pain · 2026Article
- Impact of distinct neurotransmitter release modes on neuronal signaling.Molecular psychiatry · 2026Review
- Developmental and Age-Related RAB-3 phenotypes in amicroPublication biology · 2026Article
- LRRK2 and the fragile synapse: a molecular prelude to Parkinson's disease?The Biochemical journal · 2025Review
- Botulinum neurotoxin Light Chain/A1 uses fast synaptic vesicle cycling to cleave plasma membrane bound SNAP-25.Communications biology · 2025Article
- Drosophila Atlastin regulates synaptic vesicle mobilization independent of bone morphogenetic protein signaling.Biological research · 2023Article
- Article
- The Role of Rab Proteins in Parkinson's Disease Synaptopathy.Biomedicines · 2022Review
- Genome-wide translation control analysis of developing human neurons.Molecular brain · 2022Article
- Synaptic Vesicle Recycling and the Endolysosomal System: A Reappraisal of Form and Function.Frontiers in synaptic neuroscience · 2022Review
- rab-27 acts in an intestinal pathway to inhibit axon regeneration in C. elegans.PLoS genetics · 2021Article
- Rab40-Cullin5 complex regulates EPLIN and actin cytoskeleton dynamics during cell migration.The Journal of cell biology · 2021Article
- Actions of Rab27B-GTPase on mammalian central excitatory synaptic transmission.Physiological reports · 2020Article
- Autophagy in Parkinson's Disease.Journal of molecular biology · 2020Review
- CCB is Involved in Actin-Based Axonal Transport of Selected Synaptic Proteins.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Genetic Deletion of Zebrafish Rab28 Causes Defective Outer Segment Shedding, but Not Retinal Degeneration.Frontiers in cell and developmental biology · 2020Article
- A Connected Network of Interacting Proteins Is Involved in Human-Tau Toxicity inFrontiers in neuroscience · 2020Article
- The Synaptic Vesicle Cycle Revisited: New Insights into the Modes and Mechanisms.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Review
- Article
- Deregulation of autophagy and vesicle trafficking in Parkinson's disease.Neuroscience letters · 2019Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Exo-endocytotic cycling of synaptic vesicles (SVs) is one of the most intensely studied membrane trafficking pathways. It is governed by sets of conserved proteins including Rab GTPases. Long considered to define the identity and composition of a subcellular organelle, it has become increasingly evident that multiple Rabs co-exist on intracellular compartments, each contributing to its membrane organization and specialised function. Indeed, we have recently demonstrated that at least 11 distinct Rab proteins co-exist on highly purified SVs. These include Rabs involved in exocytosis (Rab3a/b/c and Rab27b) and intermediates of SV recycling such as early endosomes (Rab4, Rab5, Rab10, Rab11b and Rab14). Interestingly, we found that while two of these proteins, namely Rab3a and Rab27b, exhibited differential cycling dynamics on SV membranes; they played complementary roles during Ca(2+)-triggered neurotransmitter release. The implications of these findings in the SV trafficking cycle are discussed.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.