ArticleJournal of signal transduction2011
Functional Diversity of the Schistosoma mansoni Tyrosine Kinases.
Article in Journal of signal transduction, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed.
- A reanalysis and integration of transcriptomics and proteomics datasets unveil novel drug targets for Mekong schistosomiasis.Scientific reports · 2024Article
- Epigenetic Markers Associated with Schistosomiasis.Helminthologia · 2021Article
- The evolution of TNF signaling in platyhelminths suggests the cooptation of TNF receptor in the host-parasite interplay.Parasites & vectors · 2020Article
- Effect of Praziquantel onPathogens (Basel, Switzerland) · 2020Article
- Identification and characterization of novel membrane-bound PRL protein tyrosine phosphatases from Setaria cervi, a bovine filarial parasite.Parasitology research · 2015Article
- Compound library screening identified Akt/PKB kinase pathway inhibitors as potential key molecules for the development of new chemotherapeutics against schistosomiasis.International journal for parasitology. Drugs and drug resistance · 2014Article
- Receptor tyrosine kinases and schistosome reproduction: new targets for chemotherapy.Frontiers in genetics · 2014Review
- New frontiers in schistosoma genomics and transcriptomics.Journal of parasitology research · 2012Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Schistosoma mansoni, one of the causative agents of schistosomiasis, has a complex life cycle infecting over 200 million people worldwide. Such a successful and prolific parasite life cycle has been shown to be dependent on the adaptive interaction between the parasite and hosts. Tyrosine kinases (TKs) play a key role in signaling pathways as demonstrated by a large body of experimental work in eukaryotes. Furthermore, comparative genomics have allowed the identification of TK homologs and provided insights into the functional role of TKs in several biological systems. Finally, TK structural biology has provided a rational basis for obtaining selective inhibitors directed to the treatment of human diseases. This paper covers the important aspects of the phospho-tyrosine signaling network in S. mansoni, Caenorhabditis elegans, and humans, the main process of functional diversification of TKs, that is, protein-domain shuffling, and also discusses TKs as targets for the development of new anti-schistosome drugs.
Identifiers
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Registered trials
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