ArticleJournal of signal transduction2011
Regulation and function of syk tyrosine kinase in mast cell signaling and beyond.
Article in Journal of signal transduction, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 50 citations in OpenAlex.
- Cumulative expression of the two Lyn isoforms creates a threshold for macrophage signaling in the absence of receptor engagement.Journal of leukocyte biology · 2026Article
- Basal phosphorylation of SHIP1 by Lyn suppresses proinflammatory signaling in the absence of a phagocytic synapse.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- Article
- Avenanthramide C from germinated oats exhibits anti-allergic inflammatory effects in mast cells.Scientific reports · 2019Article
- Tetrandrine enhances the ubiquitination and degradation of Syk through an AhR-c-src-c-Cbl pathway and consequently inhibits osteoclastogenesis and bone destruction in arthritis.Cell death & disease · 2019Article
- Effect ofEvidence-based complementary and alternative medicine : eCAM · 2019Article
- Syk and Hrs Regulate TLR3-Mediated Antiviral Response in Murine Astrocytes.Oxidative medicine and cellular longevity · 2019Article
- Role of the Spleen Tyrosine Kinase Pathway in Driving Inflammation in IgA Nephropathy.Seminars in nephrology · 2018Review
- Mercury alters endogenous phosphorylation profiles of SYK in murine B cells.BMC immunology · 2017Article
- Phosphorylation impact on Spleen Tyrosine kinase conformation by Surface Enhanced Raman Spectroscopy.Scientific reports · 2017Article
- In vitro pharmacological profiling of R406 identifies molecular targets underlying the clinical effects of fostamatinib.Pharmacology research & perspectives · 2015Article
- Tetraspanin CD151 Is a Negative Regulator of FcεRI-Mediated Mast Cell Activation.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Correlation of disease activity in proliferative glomerulonephritis with glomerular spleen tyrosine kinase expression.Kidney international · 2015Article
- Spleen tyrosine kinase inhibition attenuates autoantibody production and reverses experimental autoimmune GN.Journal of the American Society of Nephrology : JASN · 2014Article
- RegPhos 2.0: an updated resource to explore protein kinase-substrate phosphorylation networks in mammals.Database : the journal of biological databases and curation · 2014Article
- Deficiency in steroid receptor coactivator 3 enhances cytokine production in IgE-stimulated mast cells and passive systemic anaphylaxis in mice.Cell & bioscience · 2014Article
- Article
- An fc gamma receptor-mediated upregulation of the production of interleukin 10 by intravenous immunoglobulin in bone-marrow-derived mouse dendritic cells stimulated with lipopolysaccharide in vitro.Journal of signal transduction · 2013Article
- Serine phosphorylation by SYK is critical for nuclear localization and transcription factor function of Ikaros.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Once phosphorylated, tyrosines in carboxyl terminus of protein-tyrosine kinase Syk interact with signaling proteins, including TULA-2, a negative regulator of mast cell degranulation.The Journal of biological chemistry · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The protein tyrosine kinase Syk plays a critical role in FcεRI signaling in mast cells. Binding of Syk to phosphorylated immunoreceptor tyrosine-based activation motifs (p-ITAM) of the receptor subunits results in conformational changes and tyrosine phosphorylation at multiple sites that leads to activation of Syk. The phosphorylated tyrosines throughout the molecule play an important role in the regulation of Syk-mediated signaling. Reconstitution of receptor-mediated signaling in Syk(-/-) cells by wild-type Syk or mutants which have substitution of these tyrosines with phenylalanine together with in vitro assays has been useful strategies to understand the regulation and function of Syk.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.