ArticleJournal of signal transduction2011
β-Adrenergic Receptor-Stimulated Cardiac Myocyte Apoptosis: Role of β1 Integrins.
Article in Journal of signal transduction, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 34 citations in OpenAlex.
- Left Ventricular Remodeling After Myocardial Infarction-Pathophysiology, Diagnostic Approach and Management During Cardiac Rehabilitation.International journal of molecular sciences · 2025Review
- Vasoactive Agents in Burn Patients: Perspectives on Angiotensin-II.Journal of burn care & research : official publication of the American Burn Association · 2025Review
- Association of stress-induced autonomic dysfunction with heart failure in individuals with stable coronary artery disease.International journal of cardiology. Heart & vasculature · 2025Article
- The Mechanisms and Pathophysiology of Mitral Regurgitation: A Narrative Review.Annals of cardiac anaesthesia · 2025Review
- Role of Echocardiography in Diabetic Cardiomyopathy: From Mechanisms to Clinical Practice.Journal of cardiovascular development and disease · 2023Review
- Post-myocardial infarction fibrosis: Pathophysiology, examination, and intervention.Frontiers in pharmacology · 2023Review
- Left Ventricular Remodeling after Myocardial Infarction: From Physiopathology to Treatment.Life (Basel, Switzerland) · 2022Review
- Effects of fibrillin mutations on the behavior of heart muscle cells in Marfan syndrome.Scientific reports · 2020Article
- Injectable human recombinant collagen matrices limit adverse remodeling and improve cardiac function after myocardial infarction.Nature communications · 2019Article
- Renal denervation improves cardiac function by attenuating myocardiocyte apoptosis in dogs after myocardial infarction.BMC cardiovascular disorders · 2018Article
- Tumorous imaginal disc 1 (TID1) inhibits isoproterenol-induced cardiac hypertrophy and apoptosis by regulating c-terminus of hsc70-interacting protein (CHIP) mediated degradation of Gαs.International journal of medical sciences · 2018Article
- β₁-adrenoceptor stimulation promotes LPS-induced cardiomyocyte apoptosis through activating PKA and enhancing CaMKII and IκBα phosphorylation.Critical care (London, England) · 2015Article
- Protective effects of remote ischemic preconditioning in isolated rat hearts.International journal of clinical and experimental medicine · 2015Article
- Exogenous ubiquitin modulates chronic β-adrenergic receptor-stimulated myocardial remodeling: role in Akt activity and matrix metalloproteinase expression.American journal of physiology. Heart and circulatory physiology · 2012Article
- Matrix metalloproteinases in diabetic retinopathy: potential role of MMP-9.Expert opinion on investigational drugs · 2012Review
- Integrin and GPCR Crosstalk in the Regulation of ASM Contraction Signaling in Asthma.Journal of allergy · 2012Article
- Left ventricular remodelling in chronic primary mitral regurgitation: implications for medical therapy.Cardiovascular journal of AfricaReview
- Substrate stiffness affects sarcomere and costamere structure and electrophysiological function of isolated adult cardiomyocytes.Cardiovascular pathology : the official journal of the Society for Cardiovascular PathologyArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Increased sympathetic nerve activity to the myocardium is a central feature in patients with heart failure. Accumulation of catecholamines plays an important role in the pathogenesis of heart disease. Acting via β-adrenergic receptors (β-AR), catecholamines (norepinephrine and isoproterenol) increase cardiac myocyte apoptosis in vitro and in vivo. Specifically, β(1)-AR and β(2)-AR coupled to Gαs exert a proapoptotic action, while β(2)-AR coupled to Gi exerts an antiapoptotic action. β1 integrin signaling protects cardiac myocytes against β-AR-stimulated apoptosis in vitro and in vivo. Interaction of matrix metalloproteinase-2 (MMP-2) with β1 integrins interferes with the survival signals initiated by β1 integrins. This paper will discuss background information on β-AR and integrin signaling and summarize the role of β1 integrins in β-AR-stimulated cardiac myocyte apoptosis.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.