ArticleSelf/nonself2011
A role of IL-1R1 signaling in the differentiation of Th17 cells and the development of autoimmune diseases.
Article in Self/nonself, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 47 citations in OpenAlex.
- Topical interleukin 1 receptor antagonist for treatment of dry eye disease: a randomized clinical trial.JAMA ophthalmology · 2013Trial
- Interleukin-1β-Induced Inflammatory Signaling and Myelin-Related Alterations in Oligodendroglia and Schwann Cells in Multiple Sclerosis: Modulatory Effects of Ibuprofen and Flurbiprofen.Current issues in molecular biology · 2026Article
- IL-1 Receptor Contributes to the Maintenance of the Intestinal Barrier via IL-22 during Obesity and Metabolic Syndrome in Experimental Model.Microorganisms · 2024Article
- Article
- Interferon-γ controls aquaporin 4-specific Th17 and B cells in neuromyelitis optica spectrum disorder.Brain : a journal of neurology · 2024Article
- Induction of Unique STAT Heterodimers by IL-21 Provokes IL-1RI Expression on CD8Immune network · 2021Article
- Article
- Dermatophytosis in companion animals: A review.Veterinary world · 2020Review
- Shikonin Inhibits Der p 2-Induced Cytokine and Chemokine Expression in Dendritic Cells in Patients with Atopic Dermatitis.Evidence-based complementary and alternative medicine : eCAM · 2020Article
- IL-1β Induces the Rapid Secretion of the Antimicrobial Protein IL-26 from Th17 Cells.Journal of immunology (Baltimore, Md. : 1950) · 2019Article
- Increased ratio of Th17 cells to SIGIRRBiomedical reports · 2018Article
- NLRP3 Inflammasome and IL-33: Novel Players in Sterile Liver Inflammation.International journal of molecular sciences · 2018Review
- NOD-Like Receptor Protein 3 Inflammasome-Dependent IL-1β Accelerated ConA-Induced Hepatitis.Frontiers in immunology · 2018Article
- Toll-Like Receptor Pathways in Autoimmune Diseases.Clinical reviews in allergy & immunology · 2016Review
- Activated IL-1RI Signaling Pathway Induces Th17 Cell DifferentiationFrontiers in immunology · 2016Article
- Role of IL-17 in Glioma Progression.Journal of spine & neurosurgery · 2013Article
- IL-1 receptor regulates microRNA-135b expression in a negative feedback mechanism during cigarette smoke-induced inflammation.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- IL-17 mediates immunopathology in the absence of IL-10 following Leishmania major infection.PLoS pathogens · 2013Article
- IL-1 and T Helper Immune Responses.Frontiers in immunology · 2013Article
- Generation and immunologic functions of Th17 cells in malignant gliomas.Cancer immunology, immunotherapy : CII · 2013Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
IL-1 cytokine family plays a key role in the innate immune response against pathogen- and danger-associated molecular patterns. More recently, IL-1 receptor type 1 (IL-R1) signaling has been identified as a critical step in the differentiation and commitment of Th17 cells, which mediate the development of autoimmune diseases. Given its significance in the induction of the adoptive immune response, this complex signaling pathway is tightly regulated. Upon binding of IL-1 to IL-1R1, IL-1R accessory protein (AcP) is recruited to form a high affinity IL-1R1-IL-1RAcP heterodimeric receptor, which initiates the downstream signaling cascade. Multiple negative regulators of this pathway, including inhibitory membrane-bound IL-RII, secreted soluble (s)IL-1RI, sIL-RII and sIL-1RAcP, the regulatory IL-1R1 antagonist (IL-1R1a) and the IL-1R1-signlaing-induced single Ig-IL-1R-related (SIGIRR), provide a negative feedback control of this pathway, and suppress excessive IL-1 signaling and Th17 cell differentiation. IL-1R1 signaling induces human Th17 cell differentiation, leading to the expression of IL-1R-associated protein kinase (IRAK)4 and retinoic acid-related orphan nuclear hormone receptor (ROR), Th17 cell lineage transcription factors, which together with signal transducer and activator of the transcription (STAT)3, activate this cell lineage's specific cytokine expression profile, including IL-17A, IL-17F, IL-21 and IL-22. Given the role of IL-1 signaling and Th17 cells in the development of the autoinflammatory and autoimmune diseases, therapeutic strategies inhibiting IL-1R1 signaling are discussed as a novel approach for the treatment of autoimmune diseases and particularly multiple sclerosis (MS).
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.