ArticleEvidence-based complementary and alternative medicine : eCAM2011
Methylglyoxal-a potential risk factor of manuka honey in healing of diabetic ulcers.
Article in Evidence-based complementary and alternative medicine : eCAM, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 91 citations in OpenAlex.
- Manuka honey-impregnated dressings in the treatment of neuropathic diabetic foot ulcers.International wound journal · 2014Trial
- Botanical Origin-Dependent Phytochemical Profiles and Pharmaceutical Properties of Medical-Grade Honeys: Transdermal Delivery and Antibacterial Efficacy in a Wound Fluid Model.Molecules (Basel, Switzerland) · 2026Article
- Ecological, Apicultural, and Therapeutic Value ofFoods (Basel, Switzerland) · 2025Review
- Transcriptomic and metabolomic insights into the antimicrobial mechanisms ofFrontiers in plant science · 2025Article
- The Antioxidant Potential of Commercial Manuka Honey from New Zealand-Biochemical and Cellular Studies.Current issues in molecular biology · 2024Article
- Quality of Commercially Available Manuka Honey Expressed by Pollen Composition, Diastase Activity, and Hydroxymethylfurfural Content.Foods (Basel, Switzerland) · 2023Article
- Polysucrose hydrogel loaded with natural molecules/extracts for multiphase-directed sustainable wound healing.RSC medicinal chemistry · 2023Article
- Antibacterial interactions between two monofloral honeys and several topical antiseptics, including essential oils.BMC complementary medicine and therapies · 2022Article
- A Comprehensive Review of Natural Compounds for Wound Healing: Targeting Bioactivity Perspective.International journal of molecular sciences · 2022Review
- Honey: An Advanced Antimicrobial and Wound Healing Biomaterial for Tissue Engineering Applications.Pharmaceutics · 2022Review
- Antibacterial Efficacy and Healing Potential of Honey from Different Zones in Nigeria on Diabetic-Induced Wound Infection in Wistar Rats.International journal of microbiology · 2022Article
- Applications of Alginate-Based Nanomaterials in Enhancing the Therapeutic Effects of Bee Products.Frontiers in molecular biosciences · 2022Review
- Therapy of infected wounds: overcoming clinical challenges by advanced drug delivery systems.Drug delivery and translational research · 2021Review
- Honey-incorporated nanofibre reduces replicative senescence of umbilical cord-derived mesenchymal stem cells.IET nanobiotechnology · 2020Article
- Topical 5% potassium permanganate solution accelerates the healing process in chronic diabetic foot ulcers.Biomedical reports · 2018Article
- Diversity Analysis and Bioresource Characterization of Halophilic Bacteria Isolated from a South African Saltpan.Molecules (Basel, Switzerland) · 2017Article
- Smart Dressings Based on Nanostructured Fibers Containing Natural Origin Antimicrobial, Anti-Inflammatory, and Regenerative Compounds.Materials (Basel, Switzerland) · 2015Review
- Honey in the Prevention and Treatment of Infection in the CKD Population: A Narrative Review.Evidence-based complementary and alternative medicine : eCAM · 2015Review
- The Anti-Inflammatory and Antibacterial Action of Nanocrystalline Silver and Manuka Honey on the Molecular Alternation of Diabetic Foot Ulcer: A Comprehensive Literature Review.Evidence-based complementary and alternative medicine : eCAM · 2015Review
- Honey: a potential therapeutic agent for managing diabetic wounds.Evidence-based complementary and alternative medicine : eCAM · 2014Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Honey has been considered as a remedy in wound healing since ancient times. However, as yet, there are inadequate supportive robust randomized trials and experimental data to fully accept honey as an effective medical product in wound care. Manuka honey has been claimed to have therapeutic advantages over other honeys. Recently, it has been documented that the pronounced antibacterial activity of manuka honey is due, at least in part, to reactive methylglyoxal (MG). The concentration of MG in manuka honeys is up to 100-fold higher than in conventional honeys. MG is a potent protein-glycating agent and an important precursor of advanced glycation end products (AGEs). MG and AGEs play a role in the pathogenesis of impaired diabetic wound healing and can modify the structure and function of target molecules. This commentary describes the concern that MG in manuka honey may delay wound healing in diabetic patients. Further detailed research is needed to fully elucidate the participation of honey/derived MG in healing diabetic ulcers. We advocate randomized controlled trials to determine efficacy and safety of manuka honey in this population.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.