ArticleClinical & developmental immunology2011
Immune dysregulation after cardiothoracic surgery and incidental thymectomy: maintenance of regulatory T cells despite impaired thymopoiesis.
Article in Clinical & developmental immunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00263120 (Effects of Thymectomy During Cardiothoracic Surgery), which is not on this map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Thymectomy During Cardiothoracic Surgery
Who cites it
17 citing papers in PubMed, 42 citations in OpenAlex.
- Long-term immunological impairment after early thymectomy in congenital heart disease.Immunologic research · 2026Article
- Association of Preoperative Functional Status With Short-Term Major Adverse Outcomes After Cardiac Surgery.Cureus · 2025Article
- Effects of antibiotics, hospitalisation and surgical complications on self-reported immunological vulnerability following paediatric open-heart surgery and thymectomy: a single-centre retrospective cohort study.BMJ paediatrics open · 2024Article
- Immunity and inflammation: the neglected key players in congenital heart disease?Heart failure reviews · 2022Review
- Myasthenia gravis and paroxysmal nocturnal hemoglobinuria after thymectomy: A rare association.EJHaem · 2021Article
- Inborn Errors of Adaptive Immunity in Down Syndrome.Journal of clinical immunology · 2020Review
- Risk of incident autoimmune diseases in patients with thymectomy.Annals of clinical and translational neurology · 2020Article
- Systemic lupus erythematosus-myasthenia gravis overlap syndrome: Presentation and treatment depend on prior thymectomy.Clinical immunology (Orlando, Fla.) · 2018Article
- Human neonatal thymectomy induces altered B-cell responses and autoreactivity.European journal of immunology · 2017Article
- Aberrant Intrathyroid Tissue: a Report of Intrathyroid Lymph Node Metastasis and a Review of Literature.The Indian journal of surgery · 2017Article
- Autoimmunity and allergy control in adults submitted to complete thymectomy early in infancy.PloS one · 2017Article
- IL-7-Induced Proliferation of Human Naive CD4 T-Cells Relies on Continued Thymic Activity.Frontiers in immunology · 2017Article
- Human naïve regulatory T-cells feature high steady-state turnover and are maintained by IL-7.Oncotarget · 2016Article
- Neonatal thymectomy reveals differentiation and plasticity within human naive T cells.The Journal of clinical investigation · 2016Article
- Immunologic Aging in Adults with Congenital Heart Disease: Does Infant Sternotomy Matter?Pediatric cardiology · 2015Article
- CD4+ T cells in aged or thymectomized recipients of allogeneic stem cell transplantations.Biological research · 2015Article
- Elevated preoperative neutrophil/lymphocyte ratio as a predictor of increased long-term survival in minimal invasive coronary artery bypass surgery compared to sternotomy.Journal of cardiothoracic surgery · 2013Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Thymectomy is performed in infants during cardiothoracic surgery leaving many patients with reduced thympopoiesis. An association between immune disorders and regulatory T cells (Treg) after incidental thymectomy has not been investigated. Questionnaires soliciting symptoms of atopic or autoimmune disease and biomarkers were measured in children and adults with congenital heart disease and either reduced or preserved thymopoiesis. Tregs were examined. Atopic or autoimmune-like symptoms and elevated anti-dsDNA antibodies were common after surgery in individuals with low thymopoiesis. Total Treg number and function were maintained but with fewer naïve Treg. TCR spectratypes were similar to other memory T cells. These data suggest that thymectomy does not reduce total Treg number but homeostasis is affected with reduced naïve Treg. Prevalence of autoimmune or atopic symptoms after surgery is not associated with total number or proportion of Tregs but appears to be due to otherwise unknown factors that may include altered Treg homeostasis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.