ArticleSarcoma2011
Teratoma with malignant transformation: a case report with pathological, cytogenetic, and immunohistochemistry analysis.
Article in Sarcoma, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 21 citations in OpenAlex.
- Insights into Growing Teratoma Syndrome: An In-Depth Retrospective Analysis of Clinical Features and Treatment Outcomes.Indian journal of surgical oncology · 2025Article
- Article
- Mucinous Adenocarcinoma and Carcinoid Tumor Arising Within an Ovarian Mature Cystic Teratoma: A Case Report.Oman medical journal · 2023Article
- Miserable 9 Years of Life: a Misdiagnosed and Mismanaged Case of Large Retroperitoneal Teratoma.Indian journal of surgical oncology · 2020Article
- Therapeutic strategies for uncommon testis cancer histologies: teratoma with malignant transformation and malignant testicular sex cord stromal tumors.Translational andrology and urology · 2020Review
- Somatic Malignant Transformation of a Testicular Teratoma: A Case Report and an Unusual Presentation.Case reports in pathology · 2019Article
- Testicular teratomas: a growing problem?Medical oncology (Northwood, London, England) · 2018Review
- Two cases of somatic-type malignancy as a very late relapse of testicular cancer successfully managed by surgical resection.Journal of surgical case reports · 2017Article
- The Case of an Elderly Male Patient with Unknown Primary Mucinous Adenocarcinoma within Presacral Teratoma (Teratoma with Malignant Transformation).Case reports in oncological medicine · 2015Article
- Intrapulmonary cystic teratoma mimicking malignant pulmonary neoplasm.BMJ case reports · 2012Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background. Teratoma with malignant transformation (TMT) is rare and most commonly encountered in adult patient with germ cell tumor (GCT). Method. We report a rare case of testicular teratoma with metastatic TMT/embryonal rhabdomyosarcoma (ERMS). A 44-year-old man underwent right orchiectomy which revealed a malignant teratoma, he subsequently had right pneumonectomy with two pulmonary masses containing a high-grade embryonal rhabdomyosarcoma. The patient developed liver metastasis three months after initial diagnosis. He was treated with a chemotherapy regimen with vincristine, dactinomycin, and cyclophosphamide (VAC) alternating with vincristine and irinotecan (VI) with complete resolution of his liver lesion. The tumors were examined with a battery of cytogenetic, immunohistochemical, and molecular assays. Results. The malignant cells were immunohistochemically positive for desmin, myogenin, and MyoD1. Molecular cytogenetics of embryonal rhabdomyosarcoma tissue revealed the presence of i(12p). The tumor expressed high level of TOPO2A, TOPO1, MRP1, MGMT, BCRP, ERCC1, RRM1, and TS. Conclusion. The activity of topoisomerase inhibitors and the potential usefulness of topoisomerase expression as biomarkers should be further tested in aprospective study.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.