Evidence map›Paper›PMID 21776079›Full record

ReviewNature2011

Nuclear export dynamics of RNA-protein complexes.

David Grünwald, Robert H Singer, Michael Rout

Abstract readReview
In one paragraph

Review in Nature, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 102 papers.

0numbers the graph read from it
0cells of the map it votes in
102citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

102 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. RANBP17 Overexpression Restores Nucleocytoplasmic Transport and Ameliorates Neurodevelopment in Induced DYT1 Dystonia Motor Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  7. Nuclear envelope budding: Getting large macromolecular complexes out of the nucleus.BioEssays : news and reviews in molecular, cellular and developmental biology · 2024
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. An introduction to dynamic nucleoporins inJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2022
    Review
  13. Review
  14. Article
  15. Article
  16. Imaging Organization of RNA Processing within the Nucleus.Cold Spring Harbor perspectives in biology · 2021
    Review
  17. Review
  18. Distinct roles of nuclear basket proteins in directing the passage of mRNA through the nuclear pore.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  19. Article
  20. Review

42 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

David GrünwaldDelft University of Technology, Faculty of Applied Sciences, Kavli Institute of NanoScience, Department of Bionanoscience, 2628 CJ Delft, The Netherlands.
Robert H Singer
Michael Rout

Funding

NEW TOOLS FOR EXPLORING THE DYNAMIC INTERACTOME(RMI)U54RR022220 · NCRR · ROCKEFELLER UNIVERSITY · PI ROUT, MICHAEL P · 2005 to 2011
$19.3M
RNA TRANSPORT AND LOCALIZATION IN YEAST IN SITUR01GM057071 · NIGMS · YESHIVA UNIVERSITY · PI SINGER, ROBERT H · 1998 to 2019
$5.7M
Virtual Gating Machines for Protein PurificationR01GM071329 · NIGMS · ROCKEFELLER UNIVERSITY · PI ROUT, MICHAEL P · 2004 to 2013
$4.6M
LIGHT-ACTIVATED GENE EXPRESSION IN SINGLE CELLS WITHIN TISSUER01GM086217 · NIGMS · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI SINGER, ROBERT H · 2008 to 2011
$2.9M
DISSECTING THE MOLECULAR MACHINERY OF NUCLEAR TRANSPORTR01GM062427 · NIGMS · ROCKEFELLER UNIVERSITY · PI ROUT, MICHAEL P · 2001 to 2010
$2.7M
Mechanism of Actin mRNA LocalizationR01GM084364 · NIGMS · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI SINGER, ROBERT H · 2008 to 2012
$1.9M
NCRR NIH HHS RR022220NCRR NIH HHS U54 RR022220NIGMS NIH HHS GM062427NIGMS NIH HHS GM071329NIGMS NIH HHS GM84364NIGMS NIH HHS GM86217NIGMS NIH HHS R01 GM057071NIGMS NIH HHS R01 GM062427NIGMS NIH HHS R01 GM071329NIGMS NIH HHS R01 GM084364NIGMS NIH HHS R01 GM086217
6 · The paper itself

Abstract

The central dogma of molecular biology - DNA makes RNA makes proteins - is a flow of information that in eukaryotes encounters a physical barrier: the nuclear envelope, which encapsulates, organizes and protects the genome. Nuclear-pore complexes, embedded in the nuclear envelope, regulate the passage of molecules to and from the nucleus, including the poorly understood process of the export of RNAs from the nucleus. Recent imaging approaches focusing on single molecules have provided unexpected insight into this crucial step in the information flow. This review addresses the latest studies of RNA export and presents some models for how this complex process may work.

Indexed as

Active Transport, Cell NucleusCell NucleusCytoplasmHumansMicroscopyNuclear PoreRibonucleoproteinsRibosomesRNARibonucleoproteinsRNA

Identifiers

PMID21776079
PMCPMC3154952

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.