ArticleNature genetics2011
Recombination rates in admixed individuals identified by ancestry-based inference.
Article in Nature genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
66 citing papers in PubMed, 125 citations in OpenAlex.
- Article
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- Opportunities and challenges of local ancestry in genetic association analyses.American journal of human genetics · 2025Review
- Inference of Locus-Specific Population Mixtures from Linked Genome-Wide Allele Frequencies.Molecular biology and evolution · 2024Article
- Improving polygenic risk prediction in admixed populations by explicitly modeling ancestral-differential effects via GAUDI.Nature communications · 2024Article
- Recombination map tailored to Native Hawaiians may improve robustness of genomic scans for positive selection.Human genetics · 2024Article
- Admixture mapping and selection scans identify genomic regions associated with stomatal patterning and disease resistance in hybrid poplars.Ecology and evolution · 2023Article
- Strategies for the Genomic Analysis of Admixed Populations.Annual review of biomedical data science · 2023Review
- Fast, accurate local ancestry inference with FLARE.American journal of human genetics · 2023Article
- Including diverse and admixed populations in genetic epidemiology research.Genetic epidemiology · 2022Article
- The recombination landscape of the Khoe-San likely represents the upper limits of recombination divergence in humans.Genome biology · 2022Article
- Human genetic admixture through the lens of population genomics.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Review
- Fine human genetic map based on UK10K data set.Human genetics · 2022Article
- Applications of Single-Cell DNA Sequencing.Annual review of genomics and human genetics · 2021Review
- Demographic history shapes genomic ancestry in hybrid zones.Ecology and evolution · 2021Article
- Inferring recombination patterns in African populations.Human molecular genetics · 2021Review
- Human genetic admixture.PLoS genetics · 2021Review
- Tractor uses local ancestry to enable the inclusion of admixed individuals in GWAS and to boost power.Nature genetics · 2021Article
- The impact of global and local Polynesian genetic ancestry on complex traits in Native Hawaiians.PLoS genetics · 2021Article
- Identity-by-descent detection across 487,409 British samples reveals fine scale population structure and ultra-rare variant associations.Nature communications · 2020Article
6 more citing papers are in PubMed but not listed here.
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Authors and funding
19 authors at 8 institutions in 1 country.
Funding
Abstract
Studies of recombination and how it varies depend crucially on accurate recombination maps. We propose a new approach for constructing high-resolution maps of relative recombination rates based on the observation of ancestry switch points among admixed individuals. We show the utility of this approach using simulations and by applying it to SNP genotype data from a sample of 2,565 African Americans and 299 African Caribbeans and detecting several hundred thousand recombination events. Comparison of the inferred map with high-resolution maps from non-admixed populations provides evidence of fine-scale differentiation in recombination rates between populations. Overall, the admixed map is well predicted by the average proportion of admixture and the recombination rate estimates from the source populations. The exceptions to this are in areas surrounding known large chromosomal structural variants, specifically inversions. These results suggest that outside of structurally variable regions, admixture does not substantially disrupt the factors controlling recombination rates in humans.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.