ArticleNature genetics2011
Analyses of X-linked and autosomal genetic variation in population-scale whole genome sequencing.
Article in Nature genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
59 citing papers in PubMed, 1 synthesis or guideline pooled it, 102 citations in OpenAlex.
- Common X-Chromosome Variants Are Associated with Parkinson Disease Risk.Annals of neurology · 2021Pooled it
- Inferring the Relative Contributions of Evolutionary Processes Shaping X Chromosome Dynamics in the Common Marmoset (Callithrix jacchus) in the Presence of Twinning and Hematopoietic Chimerism.Genome biology and evolution · 2026Article
- Insights into X-Linked Susceptibility to Parkinson's Disease in the South African Population.medRxiv : the preprint server for health sciences · 2025Article
- X-linked competition - implications for human development and disease.Nature reviews. Genetics · 2025Review
- Comparative Patterns of Variation on the X Chromosome and Autosomes: The Role of the Breeding Sex Ratio.bioRxiv : the preprint server for biology · 2025Article
- Chromosome X-wide common variant association study in autism spectrum disorder.American journal of human genetics · 2025Article
- Chromosome X-Wide Common Variant Association Study (XWAS) in Autism Spectrum Disorder.medRxiv : the preprint server for health sciences · 2024Article
- Sirenian genomes illuminate the evolution of fully aquatic species within the mammalian superorder afrotheria.Nature communications · 2024Article
- Genetic analysis of the X chromosome in people with Lewy body dementia nominates new risk loci.NPJ Parkinson's disease · 2024Article
- Multiple Origins and Genomic Basis of Complex Traits in Sighthounds.Molecular biology and evolution · 2023Article
- Genomic and demographic processes differentially influence genetic variation across the human X chromosome.PloS one · 2023Article
- Whole-genome resequencing of wild and cultivated cannabis reveals the genetic structure and adaptive selection of important traits.BMC plant biology · 2022Article
- Evolutionary dynamics of the human pseudoautosomal regions.PLoS genetics · 2021Article
- Changes in life history and population size can explain the relative neutral diversity levels on X and autosomes in extant human populations.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Article
- The inference of sex-biased human demography from whole-genome data.PLoS genetics · 2019Article
- The Role of Phylogenetically Conserved Elements in Shaping Patterns of Human Genomic Diversity.Molecular biology and evolution · 2018Article
- Human demographic history has amplified the effects of background selection across the genome.PLoS genetics · 2018Article
- Contrasting Patterns of Genomic Diversity Reveal Accelerated Genetic Drift but Reduced Directional Selection on X-Chromosome in Wild and Domestic Sheep Species.Genome biology and evolution · 2018Article
- Genetic Diversity on the Sex Chromosomes.Genome biology and evolution · 2018Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The ratio of genetic diversity on chromosome X to that on the autosomes is sensitive to both natural selection and demography. On the basis of whole-genome sequences of 69 females, we report that whereas this ratio increases with genetic distance from genes across populations, it is lower in Europeans than in West Africans independent of proximity to genes. This relative reduction is most parsimoniously explained by differences in demographic history without the need to invoke natural selection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.