Evidence map›Paper›PMID 21775836›Full record

Trial reportObstetrics and gynecology2011

Relating pelvic pain location to surgical findings of endometriosis.

Albert L Hsu, Ninet Sinaii, James Segars, Lynnette K Nieman, Pamela Stratton

2 registry-linked trialsOpen access · greenAbstract readClinical Trial
In one paragraph

Trial report in Obstetrics and gynecology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
5.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00001848 phase2completednot on this map

The Safety and Effectiveness of Surgery With or Without Raloxifene (Evista (Trademark), Lilly) for the Treatment of Pelvic Pain Caused by Endometriosis

TypeinterventionalSponsorEunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)Ran1998 to 2006Enrolled612ConditionsEndometriosis, Pelvic PainArmsRaloxifene
NCT04318275 completednot on this mapstarted 2020, after this paper: background citation

An Early Feasibility Study to Explore a Novel Objective Pain Measurement Using a Wearable Biosensor and a Novel Mobile Platform in Patients With Endometriosis (OPINE)

TypeobservationalSponsorBiofourmis Singapore Pte Ltd.Ran2020 to 2022Enrolled90ConditionsEndometriosis
3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 77 citations in OpenAlex.

  1. Article
  2. Impact of deep or ovarian endometriosis on pelvic pain and quality of life: prospective cross-sectional ultrasound study.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Pain in Endometriosis.Frontiers in cellular neuroscience · 2020
    Review
  13. Article
  14. Article
  15. Review
  16. Observational
  17. Review
  18. Article
  19. Article
  20. Pain typology and incident endometriosis.Human reproduction (Oxford, England) · 2015
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Albert L HsuFrom the Program in Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, and the Biostatistics and Clinical Epidemiology Service, Clinical Center, National Institutes of Health, Bethesda, Maryland; and the George Washington University School of Medicine and Health Sciences, Washington, DC.
Ninet Sinaii
James Segars
Lynnette K Nieman
Pamela Stratton
Eunice Kennedy Shriver National Institute of Child Health and Human Development · US

Funding

Reproductive Endocrinology And Infertility Clinical Training ProgramZIEHD008737 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI HILL, MICAH · 2011 to 2025
$24.0M
Neural Immune and Genetic Influences on Chronic Pelvic Pain and EndometriosisZIAHD008769 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI STRATTON, PAMELA · 2009 to 2016
$2.1M
Endometrial PhysiologyZIAHD008854 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI NIEMAN, LYNNETTE · 2009 to 2015
$1.3M
Treatment Of EndometriosisZ01HD008728 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI STRATTON, PAMELA · 2001 to 2008
$559k
Intramural NIH HHS Z01 HD008728
6 · The paper itself

Abstract

objectiveTo study whether pain location is related to lesion location in women with chronic pelvic pain and biopsy-proven endometriosis.

methodsA secondary analysis was performed to compare self-reported pain location with recorded laparoscopy findings for location and characteristics of all visible lesions. All lesions were excised. Endometriosis was diagnosed using histopathology criteria. The pelvic area was divided into three anterior and two posterior regions. Lesion depth, number of lesions or endometriomas, and disease burden (defined as sum of lesion sizes, or single compared with multiple lesions) were determined for each region. Data were analyzed using t tests, Fisher exact tests, and logistic regression modeling, with P values corrected for multiple comparisons using the step-down Bonferroni method.

resultsWomen with endometriosis (n = 96) had lower body mass indexes, were more likely to be white, had more previous surgeries, and had more frequent menstrual pain and incapacitation than did chronic pain patients without endometriosis (n = 37). Overall, few patients had deeply infiltrating lesions (n = 38). Dysuria was associated with superficial bladder peritoneal lesions. Other lesions or endometriomas were not associated with pain in the same anatomic locations. Lesion depth, disease burden, and number of lesions or endometriomas were not associated with pain.

conclusionIn this group of women with biopsy-proven endometriosis, few had deeply infiltrating lesions or endometriomas. Dysuria and midline anterior pain were the only symptoms associated with the location of superficial endometriosis lesions. The lack of relationship between pain and superficial lesion location raises questions about how these lesions relate to pain. CLINICAL

trial registrationClinicalTrials.gov, www.clinicaltrials.gov, NCT00001848. LEVEL OF EVIDENCE: : II.

Indexed as

AdolescentAdultBiopsyBone Density Conservation AgentsChronic DiseaseEndometriosisFemaleHumansLaparoscopyMiddle AgedPelvic PainRaloxifene HydrochlorideYoung AdultBone Density Conservation AgentsRaloxifene Hydrochloride

Identifiers

PMID21775836
PMCPMC3155822
OpenAlexW2157609773

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.