Evidence map›Paper›PMID 21775773›Full record

ReviewReproductive sciences (Thousand Oaks, Calif.)2011

Postoperative adhesion development following cesarean and open intra-abdominal gynecological operations: a review.

Awoniyi O Awonuga, Nicole M Fletcher, Ghassan M Saed, Michael P Diamond

2 registry-linked trialsOpen access · bronzeAbstract readReview
In one paragraph

Review in Reproductive sciences (Thousand Oaks, Calif.), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 33 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 2 pooled it
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06164522 unknown statusnot on this mapstarted 2024, after this paper: background citation

Prediction of Intraoperative Adhesions Before Cesarean Section: Integrating Parameters From History, Examination, and Investigations

TypeobservationalSponsorAssiut UniversityRan2024 to 2025Enrolled146ConditionsAbdominal AdhesionArmsAbdominal ultrasound
NCT07078981 not yet recruitingnot on this mapstarted 2025, after this paper: background citation

Assessing Determinants of Headway in Evaluating Risk of Adhesion: the ADHERE Study

Typeobservational_patient_registrySponsorAlessio GiordanoRan2025 to 2027Enrolled189ConditionsAdhesive Small Bowel Obstruction, Postoperative Abdominal Adhesions, Bowel Obstruction, Abdominal Surgery Complications
3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 108 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Impact of severe intra-abdominal adhesions on early maternal complications following cesarean delivery.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2025
    Observational
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Frontiers in pharmacology · 2024
    Article
  16. Article
  17. Article
  18. Observational
  19. Article
  20. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Awoniyi O AwonugaDivision of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI 48201, USA.
Nicole M Fletcher
Ghassan M Saed
Michael P Diamond
Wayne State University · US

Funding

DETROIT REPRODUCTIVE CAREER DEVELOPMENT RESEARCH CENTERK12HD001254 · NICHD · WAYNE STATE UNIVERSITY · PI HSU, CHAUR-DONG · 1999 to 2019
$4.8M
Post-Operative Adhesions: Roles of Hypoxia in Nitric OxideR01GM069941 · NIGMS · WAYNE STATE UNIVERSITY · PI SAED, GHASSAN M · 2006 to 2009
$1.1M
NICHD NIH HHS K12 HD001254NICHD NIH HHS K12HD001254NIGMS NIH HHS 1R01 GM069941NIGMS NIH HHS R01 GM069941
6 · The paper itself

Abstract

In this review, we discuss the pathophysiology of adhesion development, the impact of physiological changes associated with pregnancy on markers of adhesion development, and the clinical implications of adhesion development following cesarean delivery (CD). Although peritoneal adhesions develop after the overwhelming majority of intra-abdominal and pelvic surgery, there is evidence in the literature that suggests that patients having CD may develop adhesions less frequently. However, adhesions continue to be a concern after CD, and are likely significant, albeit on average less than after gynecological operations, but with potential to cause significant delay in the delivery of the baby with serious, lifelong consequences. Appreciation of the pathophysiology of adhesion development described herein should allow a more informed approach to the rapidly evolving field of intra-abdominal adhesions and should serve as a reference for an evidence-based approach to consideration for the prevention and treatment of adhesions.

Indexed as

Cesarean SectionFemaleGynecologic Surgical ProceduresHumansPeritoneal DiseasesPregnancyRisk AssessmentRisk FactorsTissue AdhesionsTreatment Outcome

Identifiers

PMID21775773
PMCPMC3343100
OpenAlexW2081784349

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.