ArticleDiabetes care2011
Changes in BMI, duration of overweight and obesity, and glucose metabolism: 45 years of follow-up of a birth cohort.
Article in Diabetes care, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 59 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
59 citing papers in PubMed, 108 citations in OpenAlex.
- A body mass index over 22 kg/m2 at college age is a risk factor for future diabetes in Japanese men.PloS one · 2019Trial
- Donor-matched iPSC model reveals context-dependent T2D genetic signals in fibro-adipogenic progenitors.bioRxiv : the preprint server for biology · 2026Article
- Whole-Body [Scientific data · 2025Article
- Are associations of adulthood overweight and obesity with all-cause mortality, cardiovascular disease, and obesity-related cancer modified by comparative body weight at age 10 years in the UK Biobank study?International journal of obesity (2005) · 2025Article
- Ultraprocessed Food Consumption and Obesity Development in Canadian Children.JAMA network open · 2025Article
- The age of obesity onset affects changes in subcutaneous adipose tissue macrophages and T cells after weight loss.Frontiers in immunology · 2025Article
- Overview of Ethnobotanical-Pharmacological Studies Carried Out on Medicinal Plants from the Serra da Estrela Natural Park: Focus on Their Antidiabetic Potential.Pharmaceutics · 2024Review
- Obesity Duration and Cardiometabolic Disease.Arteriosclerosis, thrombosis, and vascular biology · 2023Review
- Factors affecting Hemoglobin A1c in the longitudinal study of the Iranian population using mixed quantile regression.Scientific reports · 2023Article
- Obesity in children and adolescents: Overview of the diagnosis and management.Chronic diseases and translational medicine · 2023Review
- Incidence of obesity across adulthood in the United States, 2001-2017-a national prospective analysis.The American journal of clinical nutrition · 2023Article
- Excessive weight gain onset-age and risk of developing diabetes mellitus: a large, prospective Chinese cohort study.Frontiers in endocrinology · 2023Article
- Association Between Weight Change During Adulthood and Chronic Kidney Disease: Results from a National Survey 2011-2018.Diabetes, metabolic syndrome and obesity : targets and therapy · 2023Article
- Body Mass Index Trajectories From Childhood to Adulthood and Age at Onset of Overweight and Obesity: The Influence of Parents' Weight Status.American journal of epidemiology · 2022Article
- The relationship of life-course patterns of adiposity with type 2 diabetes, depression, and their comorbidity in the Northern Finland Birth Cohort 1966.International journal of obesity (2005) · 2022Article
- Relationship between body roundness index and the risk of heart failure in Chinese adults: the Kailuan cohort study.ESC heart failure · 2022Article
- A retrospective cohort study on the association between poor sleep quality in junior high school students and high hemoglobin A1c level in early adults with higher body mass index values.BMC endocrine disorders · 2022Article
- Clinical Significance of Lifetime Maximum Body Mass Index in Predicting the Development of T2DM: A Prospective Study in Beijing.Frontiers in endocrinology · 2022Article
- Factors Associated with Hemoglobin A1c Level Among Women Without Prior Diabetes Diagnosis in Rural Areas of Central South China: A Cross-Sectional Study.International journal of women's health · 2022Article
- Body weight, diabetes incidence vascular events and survival 15 years after very low calorie diet in community medical clinics in the UK.BMJ nutrition, prevention & health · 2022Article
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
objectiveLong-term implications of childhood obesity and BMI change over the life course for risk of type 2 diabetes remain uncertain. The objective was to establish whether there are effects on adult glucose metabolism of 1) sensitive periods of BMI gain or 2) long duration of overweight and obesity. RESEARCH DESIGN AND
methodsParticipants in the 1958 British birth cohort with child to adult BMI and glycosylated hemoglobin (HbA(1c)) at 45 years (n = 7,855).
resultsPrevalence of type 2 diabetes or HbA(1c) ≥7 was 2%. BMI gains in child- and adulthood were associated with higher HbA(1c): for every SD of 5-year BMI increase from 0 to 7 years, there was a 75% (95% CI 1.42-2.16) increased risk of HbA(1c) ≥7, increasing to a 4.7-fold (3.12-7.00) risk for the interval 23-33 years. Associations for BMI gain in adulthood were related to attained BMI but were independent for the longer period birth (or 7 years) to 45 years. Duration of obesity was also associated with HbA(1c); compared with the never obese, those with childhood onset had a 23.9-fold risk (13.5-42.1) of HbA(1c) ≥7%; odds ratios were 16.0 (10.6-24.2) and 2.99 (1.77-5.03), respectively, for young and midadulthood onset. Similar trends by onset age were found in mean HbA(1c) levels and for onset of overweight. Those with the earliest age of onset had higher BMI and waist circumference at 45 years, which markedly explained the associations for onset age and HbA(1c).
conclusionsExcessive BMI gain across the life span and earlier onset of overweight/obesity are associated with impaired glucose metabolism, in part through attained adult BMI.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.