ArticleNeurology2011
Event-related potential markers of brain changes in preclinical familial Alzheimer disease.
Article in Neurology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03676881 (Longitudinal Validation of a Computerized Cognitive Battery), which is not on this map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Longitudinal Validation of a Computerized Cognitive Battery (Cognigram) in the Diagnosis of Mild Cognitive Impairment and Alzheimer's Disease
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- Diagnostic utility of electrophysiological markers for early and differential diagnosis of Alzheimer's, Frontotemporal, and Lewy Body dementias: A systematic review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Pooled it
- Applications of event-related potentials in Alzheimer's disease: a systematic review and analysis.Frontiers in aging neuroscience · 2025Review
- Cognitive Outcomes in Autosomal-Dominant Alzheimer's Disease: A Comprehensive Review from a Colombian Kindred with the Presenilin-1 E280A Mutation.Journal of Alzheimer's disease : JAD · 2024Review
- The Use of Event Related Potentials to Predict Amyloid PET Status Among Patients from a Memory Disorders Clinic.Journal of Alzheimer's disease : JAD · 2024Article
- Visual-spatial processing impairment in the occipital-frontal connectivity network at early stages of Alzheimer's disease.Frontiers in aging neuroscience · 2023Article
- Prefrontal EEG slowing, synchronization, and ERP peak latency in association with predementia stages of Alzheimer's disease.Frontiers in aging neuroscience · 2023Article
- The Multi-Partner Consortium to Expand Dementia Research in Latin America (ReDLat): Driving Multicentric Research and Implementation Science.Frontiers in neurology · 2021Review
- Destruction of ERP responses to deviance in an auditory oddball paradigm in amyloid infusion mice with memory deficits.PloS one · 2020Article
- Biological and Cognitive Markers of Presenilin1 E280A Autosomal Dominant Alzheimer's Disease: A Comprehensive Review of the Colombian Kindred.The journal of prevention of Alzheimer's disease · 2019Review
- Neurophysiological signatures of Alzheimer's disease and frontotemporal lobar degeneration: pathology versus phenotype.Brain : a journal of neurology · 2018Article
- Dynamic Causal Modeling of Preclinical Autosomal-Dominant Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2018Article
- Increased Amplitude of the P3a ERP Component as a Neurocognitive Marker for Differentiating Amnestic Subtypes of Mild Cognitive Impairment.Frontiers in aging neuroscience · 2018Article
- A Three-Factor Structure of Cognitive Functioning Among Unimpaired Carriers and Non-Carriers of Autosomal-Dominant Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2018Article
- Event-related potentials during sustained attention and memory tasks: Utility as biomarkers for mild cognitive impairment.Alzheimer's & dementia (Amsterdam, Netherlands) · 2018Article
- A cognitive electrophysiological signature differentiates amnestic mild cognitive impairment from normal aging.Alzheimer's research & therapy · 2017Article
- Successful Object Encoding Induces Increased Directed Connectivity in Presymptomatic Early-Onset Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2017Article
- Visual Dysfunction in Posterior Cortical Atrophy.Frontiers in neurology · 2017Review
- Preclinical Alzheimer's disease: Definition, natural history, and diagnostic criteria.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2016Review
- A clinical trial to validate event-related potential markers of Alzheimer's disease in outpatient settings.Alzheimer's & dementia (Amsterdam, Netherlands) · 2015Article
- Brain Imaging and Blood Biomarker Abnormalities in Children With Autosomal Dominant Alzheimer Disease: A Cross-Sectional Study.JAMA neurology · 2015Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
objectivesEvent-related potentials (ERPs) can reflect differences in brain electrophysiology underlying cognitive functions in brain disorders such as dementia and mild cognitive impairment. To identify individuals at risk for Alzheimer disease (AD) we used high-density ERPs to examine brain physiology in young presymptomatic individuals (average age 34.2 years) who carry the E280A mutation in the presenilin-1 (PSEN1) gene and will go on to develop AD around the age of 45.
methodsTwenty-one subjects from a Colombian population with familial AD participated: 10 presymptomatic subjects positive for the PSEN1 mutation (carriers) and 11 siblings without the mutation (controls). Subjects performed a visual recognition memory test while 128-channel ERPs were recorded.
resultsDespite identical behavioral performance, PSEN1 mutation carriers showed less positivity in frontal regions and more positivity in occipital regions, compared to controls. These differences were more pronounced during the 200-300 msec period. Discriminant analysis at this time interval showed promising sensitivity (72.7%) and specificity (81.8%) of the ERP measures to predict the presence of AD pathology.
conclusionsPresymptomatic PSEN1 mutation carriers show changes in brain physiology that can be detected by high-density ERPs. The relative differences observed showing greater frontal positivity in controls and greater occipital positivity in carriers indicates that control subjects may use frontally mediated processes to distinguish between studied and unstudied visual items, whereas carriers appear to rely more upon perceptual details of the items to distinguish between them. These findings also demonstrate the potential usefulness of ERP brain correlates as preclinical markers of AD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.