ArticleJournal of neurophysiology2011
Coding movement direction by burst firing in electrosensory neurons.
Article in Journal of neurophysiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Distributed burst firing mediates optimized cortical encoding of natural self-motion.Science advances · 2026Article
- In vivo neural activity of electrosensory pyramidal cells: Biophysical characterization and phenomenological modeling.PLoS computational biology · 2025Article
- Article
- Population Coding of Natural Electrosensory Stimuli by Midbrain Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Variable but not random: temporal pattern coding in a songbird brain area necessary for song modification.Journal of neurophysiology · 2021Article
- Serotonergic Modulation of Sensory Neuron Activity and Behavior inFrontiers in integrative neuroscience · 2020Article
- Novel Functions of Feedback in Electrosensory Processing.Frontiers in integrative neuroscience · 2019Article
- Descending pathways generate perception of and neural responses to weak sensory input.PLoS biology · 2018Article
- Social context differentially modulates activity of two interneuron populations in an avian basal ganglia nucleus.Journal of neurophysiology · 2016Article
- Adaptation to second order stimulus features by electrosensory neurons causes ambiguity.Scientific reports · 2016Article
- Burst Firing in the Electrosensory System of Gymnotiform Weakly Electric Fish: Mechanisms and Functional Roles.Frontiers in computational neuroscience · 2016Review
- Parallel sparse and dense information coding streams in the electrosensory midbrain.Neuroscience letters · 2015Article
- Electrosensory Midbrain Neurons Display Feature Invariant Responses to Natural Communication Stimuli.PLoS computational biology · 2015Article
- Serotonin modulates electrosensory processing and behavior via 5-HT2-like receptors.Neuroscience · 2014Article
- The role of coupling strength and internal delay between compartments in shaping the bursting behavior of cortical neuron.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2014Article
- A neural code for looming and receding motion is distributed over a population of electrosensory ON and OFF contrast cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Motion processing across multiple topographic maps in the electrosensory system.Physiological reports · 2014Article
- Temporal characteristics of gustatory responses in rat parabrachial neurons vary by stimulus and chemosensitive neuron type.PloS one · 2013Article
- Parallel coding of first- and second-order stimulus attributes by midbrain electrosensory neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Bursts and isolated spikes code for opposite movement directions in midbrain electrosensory neurons.PloS one · 2012Article
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Authors and funding
3 authors.
Funding
Abstract
Directional selectivity, in which neurons respond strongly to an object moving in a given direction ("preferred") but respond weakly or not at all to an object moving in the opposite direction ("null"), is a critical computation achieved in brain circuits. Previous measures of direction selectivity have compared the numbers of action potentials elicited by each direction of movement, but most sensory neurons display patterning, such as bursting, in their spike trains. To examine the contribution of patterned responses to direction selectivity, we recorded from midbrain neurons in weakly electric fish and found that most neurons responded with a combination of both bursts and isolated spikes to moving object stimuli. In these neurons, we separated bursts and isolated spikes using an interspike interval (ISI) threshold. The directional bias of bursts was significantly higher than that of either the full spike train or the isolated spike train. To examine the encoding and decoding of bursts, we built biologically plausible models that examine 1) the upstream mechanisms that generate these spiking patterns and 2) downstream decoders of bursts. Our model of upstream mechanisms uses an interaction between afferent input and subthreshold calcium channels to give rise to burst firing that occurs preferentially for one direction of movement. We tested this model in vivo by application of calcium antagonists, which reduced burst firing and eliminated the differences in direction selectivity between bursts, isolated spikes, and the full spike train. Our model of downstream decoders used strong synaptic facilitation to achieve qualitatively similar results to those obtained using the ISI threshold criterion. This model shows that direction selective information carried by bursts can be decoded by downstream neurons using biophysically plausible mechanisms.
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