ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2011
Effect of sniffing on the temporal structure of mitral/tufted cell output from the olfactory bulb.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers.
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Who cites it
79 citing papers in PubMed.
- Fat sensory cues in early life program central response to food and obesity.Nature metabolism · 2025Article
- Mouse olfactory system acts as anemo-detector and anemo-discriminator.Science advances · 2025Article
- Design Principles From Natural Olfaction for Electronic Noses.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
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- Cell type-specific and frequency-dependent centrifugal modulation in olfactory bulb output neurons in vivo.Journal of neurophysiology · 2024Article
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- Frequency-dependent centrifugal modulation of the activity of different classes of mitral and tufted cells in olfactory bulb.Journal of neurophysiology · 2023Article
- Characterization of Retronasal Airflow Patterns during Intraoral Fluid Discrimination Using a Low-Cost, Open-Source Biosensing Platform.Sensors (Basel, Switzerland) · 2022Article
- Disinhibitory Circuitry Gates Associative Synaptic Plasticity in Olfactory Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
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- Olfactory Information Storage Engages Subcortical and Cortical Brain Regions That Support Valence Determination.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
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- Human hippocampal connectivity is stronger in olfaction than other sensory systems.Progress in neurobiology · 2021Article
- Changes in pairwise correlations during running reshape global network state in the main olfactory bulb.Journal of neurophysiology · 2021Article
- Stimulus Driven Functional Transformations in the Early Olfactory System.Frontiers in cellular neuroscience · 2021Article
- Circuit Contributions to Sensory-Driven Glutamatergic Drive of Olfactory Bulb Mitral and Tufted Cells During Odorant Inhalation.Frontiers in neural circuits · 2021Article
- Dynamic Impairment of Olfactory Behavior and Signaling Mediated by an Olfactory Corticofugal System.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Differential Impacts of Repeated Sampling on Odor Representations by Genetically-Defined Mitral and Tufted Cell Subpopulations in the Mouse Olfactory Bulb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- CCKergic Tufted Cells Differentially Drive Two Anatomically Segregated Inhibitory Circuits in the Mouse Olfactory Bulb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
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19 more citing papers are in PubMed but not listed here.
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2 authors.
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Abstract
Neural activity underlying odor representations in the mammalian olfactory system is strongly patterned by respiratory behavior. These dynamics are central to many models of olfactory information processing. We have found previously that sensory inputs to the olfactory bulb change both their magnitude and temporal structure as a function of sniff frequency. Here, we ask how sniff frequency affects responses of mitral/tufted (MT) cells--the principal olfactory bulb output neurons. We recorded from MT cells in anesthetized rats while reproducing sniffs recorded previously from awake animals and varying sniff frequency. The dynamics of a sniff-evoked response were consistent from sniff to sniff but varied across cells. Compared to the dynamics of receptor neuron activation by the same sniffs, the MT response was shorter and faster, reflecting a temporal sharpening of sensory inputs. Increasing sniff frequency led to moderate attenuation of MT response magnitude and significant changes in the temporal structure of the sniff-evoked MT cell response. Most MT cells responded with a shorter duration and shorter rise-time spike burst as sniff frequency increased, reflecting increased temporal sharpening of inputs by the olfactory bulb. These temporal changes were necessary and sufficient to maintain respiratory modulation in the MT cell population across the range of sniff frequencies expressed during behavior. These results suggest that the input-output relationship in the olfactory bulb varies dynamically as a function of sniff frequency and that one function of the postsynaptic network is to maintain robust temporal encoding of odor information across different odor sampling strategies.
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