ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2011
Combined LTP and LTD of modulatory inputs controls neuronal processing of primary sensory inputs.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 24 citations in OpenAlex.
- Sparsely Distributed, Pre-synaptic Kv3 KFrontiers in cellular neuroscience · 2021Article
- Neurokinin 1 receptor activation in the rat spinal cord maintains latent sensitization, a model of inflammatory and neuropathic chronic pain.Neuropharmacology · 2020Article
- Weak electric fields promote resonance in neuronal spiking activity: Analytical results from two-compartment cell and network models.PLoS computational biology · 2019Article
- Serotonergic Modulation of Sensory Representation in a Central Multisensory Circuit Is Pathway Specific.Cell reports · 2017Article
- Evidence of activity-dependent plasticity in the dorsal cochlear nucleus, in vivo, induced by brief sound exposure.Hearing research · 2016Article
- Article
- Stimulus-timing-dependent modifications of rate-level functions in animals with and without tinnitus.Journal of neurophysiology · 2015Article
- NMDA Receptors Mediate Stimulus-Timing-Dependent Plasticity and Neural Synchrony in the Dorsal Cochlear Nucleus.Frontiers in neural circuits · 2015Article
- Chemical synaptic transmission onto superficial stellate cells of the mouse dorsal cochlear nucleus.Journal of neurophysiology · 2014Article
- Stimulus timing-dependent plasticity in dorsal cochlear nucleus is altered in tinnitus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Stimulus-timing dependent multisensory plasticity in the guinea pig dorsal cochlear nucleus.PloS one · 2013Article
- Diverse levels of an inwardly rectifying potassium conductance generate heterogeneous neuronal behavior in a population of dorsal cochlear nucleus pyramidal neurons.Journal of neurophysiology · 2012Article
- Noise overexposure alters long-term somatosensory-auditory processing in the dorsal cochlear nucleus--possible basis for tinnitus-related hyperactivity?The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Balanced synaptic input shapes the correlation between neural spike trains.PLoS computational biology · 2011Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
A hallmark of brain organization is the integration of primary and modulatory pathways by principal neurons. However, the pathway interactions that shape primary input processing remain unknown. We investigated this problem in mouse dorsal cochlear nucleus (DCN) where principal cells integrate primary, auditory nerve input with modulatory, parallel fiber input. Using a combined experimental and computational approach, we show that combined LTP and LTD of parallel fiber inputs to DCN principal cells and interneurons, respectively, broaden the time window within which synaptic inputs summate. Enhanced summation depolarizes the resting membrane potential and thus lowers the response threshold to auditory nerve inputs. Combined LTP and LTD, by preserving the variance of membrane potential fluctuations and the membrane time constant, fixes response gain and spike latency as threshold is lowered. Our data reveal a novel mechanism mediating adaptive and concomitant homeostatic regulation of distinct features of neuronal processing of sensory inputs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.