ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2011
The role of interneurons in shaping Purkinje cell responses in the cerebellar cortex.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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56 citing papers in PubMed, 95 citations in OpenAlex.
- Synchronous climbing fiber activity enables instructive signaling for cerebellar learning through modulation of disinhibitory circuits.Nature neuroscience · 2026Article
- Purkinje Cell Collaterals Preferentially Target a Subtype of Molecular Layer Interneuron.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Effects of Short-Term Synaptic Plasticity in Feedforward Inhibitory Circuits on Cerebellar Responses to Repetitive Sensory Input.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- All-optical voltage interrogation for probing synaptic plasticity in vivo.Nature communications · 2025Article
- A theory of cerebellar learning as spike-based reinforcement learning in continuous time and space.PNAS nexus · 2025Article
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- Differential Modulation of Cerebellar Flocculus Unipolar Brush Cells during Vestibular Compensation.Biomedicines · 2023Article
- Putting forward a model for the role of the cerebellum in cocaine-induced pavlovian memory.Frontiers in systems neuroscience · 2023Article
- Selective inhibition of excitatory synaptic transmission alters the emergent bursting dynamics ofFrontiers in neural circuits · 2023Article
- Article
- Synchronous spiking of cerebellar Purkinje cells during control of movements.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Cerebellar molecular layer interneurons are dispensable for cued and contextual fear conditioning.Scientific reports · 2020Article
- Feed-forward recruitment of electrical synapses enhances synchronous spiking in the mouse cerebellar cortex.eLife · 2020Article
- Article
- Microcircuit Rules Governing Impact of Single Interneurons on Purkinje Cell Output In Vivo.Cell reports · 2020Article
- Article
- Simulation of a Human-Scale Cerebellar Network Model on the K Computer.Frontiers in neuroinformatics · 2020Article
- Molecular layer interneurons shape the spike activity of cerebellar Purkinje cells.Scientific reports · 2019Article
- NeuroD2 controls inhibitory circuit formation in the molecular layer of the cerebellum.Scientific reports · 2019Article
- Motor context dominates output from purkinje cell functional regions during reflexive visuomotor behaviours.eLife · 2019Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The well established anatomy of the cerebellar cortex has led to suggestions that cerebellar molecular layer interneurons laterally inhibit Purkinje cells. In support of the anatomical predictions, on-beam excitation and off-beam inhibition of Purkinje cells have been shown to occur when the surface of the cerebellum is electrically excited. Patchy excitation of Purkinje cells with flanking inhibition of sagittally oriented Purkinje cells have also been demonstrated following peripheral stimulation in vivo. To extend these observations, we mapped the functional connectivity between granule cells, molecular layer interneurons, and Purkinje cells in rats. Patches of granule cells were asynchronously activated by photostimulation to mimic their excitation by a mossy fiber as it occurs in vivo. We found with remarkable consistency that, in the sagittal orientation, granule cells elicit a stereotypic set of responses. Granule cells immediately underneath a Purkinje cell provide pure excitation. Granule cells positioned 340-400 μm laterally provided pure inhibition, consistent with the lateral inhibition proposed earlier. The net effect of exciting granule cells in between these two extremes was to provide a systematic change in the response of Purkinje cells, from net excitation to net inhibition moving laterally from the Purkinje cell. In contrast to the sagittal orientation, in the coronal orientation the organization of Purkinje cell responses with granule cell activation was remarkably different. Independent of the location of granule cells, within the 480 μm lateral distance examined, molecular layer interneurons reduced the strength of granule cell inputs to Purkinje cells to a comparable extent.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.