ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2011
Endogenous patterns of activity are required for the maturation of a motor network.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed.
- Distinct and common dynamics of central brain spontaneous neuronal activity across cell types during Drosophila pupal development.Scientific reports · 2026Article
- Maturation of GABAergic signalling times the opening of a critical period in Drosophila melanogaster.Scientific reports · 2025Article
- Mitochondrial ROS and HIF-1α signaling mediate synaptic plasticity in the critical period.PLoS biology · 2025Article
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- Puckered and JNK signaling in pioneer neurons coordinates the motor activity of the Drosophila embryo.Nature communications · 2023Article
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- Critical periods inFrontiers in physiology · 2022Review
- Mechanosensory input during circuit formation shapes Drosophila motor behavior through patterned spontaneous network activity.Current biology : CB · 2021Article
- Nitric oxide mediates activity-dependent change to synaptic excitation during a critical period in Drosophila.Scientific reports · 2021Article
- Pupal behavior emerges from unstructured muscle activity in response to neuromodulation ineLife · 2021Article
- Astrocytes close a motor circuit critical period.Nature · 2021Article
- Review
- TheFrontiers in neural circuits · 2021Review
- Review
- Modelling the mechanics of exploration in larval Drosophila.PLoS computational biology · 2019Article
- The brain is required for normal muscle and nerve patterning during early Xenopus development.Nature communications · 2017Article
- The Hunchback temporal transcription factor establishes, but is not required to maintain, early-born neuronal identity.Neural development · 2017Article
- Article
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Authors and funding
3 authors.
Funding
Abstract
Many parts of the nervous system become active before development is complete, including the embryonic spinal cord. Remarkably, although the subject has been debated for over a century (Harrison, 1904), it is still unclear whether such activity is required for normal development of motor circuitry. In Drosophila, embryonic motor output is initially poorly organized, and coordinated crawling-like behavior gradually emerges over the subsequent phase of development. We show that reversibly blocking synaptic transmission during this phase severely delays the first appearance of coordinated movements. When we interfere with the pattern of neuronal firing during this period, coordination is also delayed or blocked. We conclude that there is a period during which endogenous patterns of neuronal activity are required for the normal development of motor circuits in Drosophila.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.