Evidence map›Paper›PMID 21775583›Full record

ReviewThe Journal of general virology2011

The natural history of early hepatitis C virus evolution; lessons from a global outbreak in human immunodeficiency virus-1-infected individuals.

Emma C Thomson, Jennifer A Smith, Paul Klenerman

Open access · hybridAbstract readReview
In one paragraph

Review in The Journal of general virology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. Laboratory Diagnosis and Monitoring of Viral Hepatitis.Gastroenterology clinics of North America · 2019
    Review
  3. Review
  4. Mononuclear phagocyte system in hepatitis C virus infection.World journal of gastroenterology · 2018
    Review
  5. Review
  6. Review
  7. Article
  8. Hepatitis C.Lancet (London, England) · 2015
    Review
  9. Article
  10. Update on Hepatitis C Virus and HIV Coinfection.Journal of clinical and translational hepatology · 2013
    Review
  11. Review
  12. Natural history of HCV infection.Hepatology international · 2012
    Article
  13. Profibrogenic chemokines and viral evolution predict rapid progression of hepatitis C to cirrhosis.Proceedings of the National Academy of Sciences of the United States of America · 2012
    Article
  14. Review
  15. Update on hepatitis C virus-specific immunity.Current opinion in HIV and AIDS · 2011
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Emma C ThomsonDepartment of Hepatology, Imperial College London, Norfolk Place, London W2 1PG, UK.
Jennifer A SmithPeter Medawar Building for Pathogen Research, University of Oxford, South Parks Road, Oxford OX1 3SY, UK.
Paul KlenermanPeter Medawar Building for Pathogen Research, University of Oxford, South Parks Road, Oxford OX1 3SY, UK.
University of Oxford · GBMedawar Building for Pathogen Research · GB

Funding

Virology CoreU19AI082630 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI RAYMOND T CHUNG, GEORG Michael LAUER · 2009 to 2026
$48.1M
NIAID NIH HHS 1U19AI082630-01NIAID NIH HHS U19 AI082630Wellcome Trust 091663Wellcome Trust WT083690
6 · The paper itself

Abstract

New insights into the early viral evolution and cellular immune response during acute hepatitis C virus (HCV) infection are being gained following a global outbreak in human immunodeficiency virus-1 (HIV)-positive men who have sex with men. Cross-sectional and longitudinal sequence analysis at both the population and individual level have facilitated tracking of the HCV epidemic across the world and enabled the development of tests of viral diversity in individual patients in order to predict spontaneous clearance of HCV and response to treatment. Immunological studies in HIV-positive cohorts have highlighted the role of the CD4+ T-cell response in the control of early HCV infection and will increase the opportunity for the identification of protective epitopes that could be used in future vaccine development.

Indexed as

PandemicsCD4-Positive T-LymphocytesHepacivirusHepatitis CHIV-1HIV InfectionsHomosexuality, MaleHumansMale

Identifiers

PMID21775583
PMCPMC3347798
OpenAlexW2132404617

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.