Trial reportThe American journal of clinical nutrition2011
Intake of fish oil during pregnancy and adiposity in 19-y-old offspring: follow-up on a randomized controlled trial.
Trial report in The American journal of clinical nutrition, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01353807 (Impact of Fish Oil Supplementation in 3rd Trimester of Pregnancy on Maternal and Offspring Health), which is not on this map. Cited by 19 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Impact of Fish Oil Supplementation in 3rd Trimester of Pregnancy on Maternal and Offspring Health
Who cites it
19 citing papers in PubMed, 5 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Early-Life Nutrition Interventions and Associated Long-Term Cardiometabolic Outcomes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Advances in nutrition (Bethesda, Md.) · 2021Pooled it
- The effectiveness of ω-3 polyunsaturated fatty acid interventions during pregnancy on obesity measures in the offspring: an up-to-date systematic review and meta-analysis.European journal of nutrition · 2019Pooled it
- Omega-3 fatty acid addition during pregnancy.The Cochrane database of systematic reviews · 2018Pooled it
- Maternal prenatal and/or postnatal n-3 long chain polyunsaturated fatty acids (LCPUFA) supplementation for preventing allergies in early childhood.The Cochrane database of systematic reviews · 2015Pooled it
- Effect of maternal n-3 long-chain polyunsaturated fatty acid supplementation during pregnancy and/or lactation on adiposity in childhood: a systematic review and meta-analysis of randomized controlled trials.European journal of clinical nutrition · 2014Pooled it
- Effect of fish oil supplementation in pregnancy on bone, lean, and fat mass at six years: randomised clinical trial.BMJ (Clinical research ed.) · 2018Trial
- Trial
- Maternal docosahexaenoic acid and eicosapentaenoic acid supplementation: effects and mechanisms on lipid metabolism in the offspring.Frontiers in nutrition · 2026Review
- Growth and adiposity in newborns study (GAINS): The influence of prenatal DHA supplementation protocol.Contemporary clinical trials · 2023Article
- Fish Intake in Pregnancy and Offspring Metabolic Parameters at Age 9⁻16-Does Gestational Diabetes Modify the Risk?Nutrients · 2018Article
- Prenatal n-3 long-chain fatty acid status and offspring metabolic health in early and mid-childhood: results from Project Viva.Nutrition & diabetes · 2018Article
- Fish oil supplementation to rats fed high-fat diet during pregnancy prevents development of impaired insulin sensitivity in male adult offspring.Scientific reports · 2017Article
- Maternal plasma polyunsaturated fatty acid levels during pregnancy and childhood lipid and insulin levels.Nutrition, metabolism, and cardiovascular diseases : NMCD · 2017Article
- Maternal plasma PUFA concentrations during pregnancy and childhood adiposity: the Generation R Study.The American journal of clinical nutrition · 2016Article
- Maternal fish consumption during pregnancy and BMI in children from birth up to age 14 years: the PIAMA cohort study.European journal of nutrition · 2016Article
- Article
- The effect of long-chain polyunsaturated fatty acids intake during pregnancy on adiposity of healthy full-term offspring at birth.Journal of perinatology : official journal of the California Perinatal Association · 2015Article
- Maternal plasma polyunsaturated fatty acid status in late pregnancy is associated with offspring body composition in childhood.The Journal of clinical endocrinology and metabolism · 2013Article
- Lipid Profile Scores Predict Severity of Pemphigus: A Cross-Sectional Study.Indian journal of dermatologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundIt is well established that obesity tends to track from early childhood into adult life. Studies in experimental animals have suggested that changes in the peri- and early postnatal intake of n-3 (omega-3) polyunsaturated acids can affect the development of obesity in adult life.
objectiveThe aim of the current study was to investigate the effect of daily supplementation with 2.7 g long-chain n-3 fatty acids during the third trimester of pregnancy on adiposity in 19-y-old offspring.
designThe study was based on follow-up of a randomized controlled trial from 1990, in which 533 pregnant women were randomly assigned to receive fish oil, olive oil, or no oil. At ≈19 y of age, the offspring of subjects from the randomized controlled trial were invited to undergo a physical examination, including anthropometric measurements and fasting blood sampling. The blood sample was analyzed for insulin, glucose, glycated hemoglobin, leptin, adiponectin, insulin-like growth factor I, and high-sensitivity C-reactive protein. Multiple linear regression modeling, adjusted for sex, smoking, and parental overweight, was used to estimate the effect of fish oil relative to that of olive oil on BMI (in kg/m(2)), waist circumference, and biochemical measures.
resultsA total of 243 of the offspring were followed up. We found no difference between the fish-oil and olive oil groups in BMI (0.13; -0.92, 1.17) or waist circumference (0.7 cm; -2.1, 3.4 cm). Overall, results of the biochemical analyses supported the finding of no difference between the groups.
conclusionWe detected no effect of fish-oil supplementation during pregnancy on offspring adiposity in adolescence.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.