ArticleEnvironmental health perspectives2011
Stress during pregnancy and offspring pediatric disease: A National Cohort Study.
Article in Environmental health perspectives, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed, 129 citations in OpenAlex.
- Sleep, evening light exposure and perceived stress in healthy nulliparous women in the third trimester of pregnancy.PloS one · 2021Trial
- COLLABORATIVE CARE FOR PERINATAL DEPRESSION IN SOCIOECONOMICALLY DISADVANTAGED WOMEN: A RANDOMIZED TRIAL.Depression and anxiety · 2015Trial
- Improving ambulatory saliva-sampling compliance in pregnant women: a randomized controlled study.PloS one · 2014Trial
- Intergenerational effects of the microbiota on neurodevelopment: mechanisms and therapeutic perspectives.Acta pharmacologica Sinica · 2026Review
- Article
- Unraveling sexually dimorphic offspring behaviors: maternal premating stress and the neuro-microbial-metabolic network.Molecular psychiatry · 2026Article
- Partner military deployment during wartime is associated with maternal depression and impaired maternal-infant attachment: a matched-control study from the Israel-Hamas war.Archives of women's mental health · 2025Article
- The Effect of Maternal Stress on 11beta-Hydroxysteroid Dehydrogenase Activity During Pregnancy: Evidence for Potential Pregnancy Complications and Consequences on Fetal Development and Metabolism.International journal of molecular sciences · 2025Review
- Perceived stress across population segments characterized by differing stressor profiles-A latent class analysis.PloS one · 2025Article
- Depression, anxiety, and stress in pregnancy and postpartum: A longitudinal study during the COVID-19 pandemic.Midwifery · 2023Article
- Investigating the role of relationship satisfaction and paternal psychological distress during pregnancy on offspring health in early life.BJPsych open · 2023Article
- Prenatal stress induces changes in PAR2- and M3-dependent regulation of colon primitive cells.American journal of physiology. Gastrointestinal and liver physiology · 2022Article
- Screening of psychiatric disorders in women with high-risk pregnancy: Accuracy of three psychological tools.Health science reports · 2022Article
- Programming of Vascular Dysfunction by Maternal Stress: Immune System Implications.Frontiers in physiology · 2022Review
- Natural history and associated early life factors of childhood asthma: a population registry-based cohort study in Denmark.BMJ open · 2021Article
- Prenatal stress leads to deficits in brain development, mood related behaviors and gut microbiota in offspring.Neurobiology of stress · 2021Article
- Trends of Perinatal Stress, Anxiety, and Depression and Their Prediction on Postpartum Depression.International journal of environmental research and public health · 2021Article
- Maternal migraine and the risk of psychiatric disorders in offspring: a population-based cohort study.Epidemiology and psychiatric sciences · 2021Article
- The relative importance of work-related and non-work-related stressors and perceived social support on global perceived stress in a cross-sectional population-based sample.BMC public health · 2021Article
- Stressors, coping, and resources needed during the COVID-19 pandemic in a sample of perinatal women.BMC pregnancy and childbirth · 2021Article
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Authors and funding
5 authors at 3 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIdentifying risk factors for adverse health outcomes in children is important. The intrauterine environment plays a pivotal role for health and disease across life.
objectivesWe conducted a comprehensive study to determine whether common psychosocial stress during pregnancy is a risk factor for a wide spectrum of pediatric diseases in the offspring.
methodsThe study was conducted using prospective data in a population-based sample of mothers with live singleton births (n = 66,203; 71.4% of those eligible) from the Danish National Birth Cohort. We estimated the association between maternal stress during pregnancy (classified based on two a priori-defined indicators of common stress forms, life stress and emotional stress) and offspring diseases during childhood (grouped into 16 categories of diagnoses from the International Classification of Diseases, 10th Revision, based on data from national registries), controlling for maternal stress after pregnancy.
resultsMedian age at end of follow-up was 6.2 (range, 3.6-8.9) years. Life stress (highest compared with lowest quartile) was associated with an increased risk of conditions originating in the perinatal period [odds ratio (OR) = 1.13; 95% confidence interval (CI): 1.06, 1.21] and congenital malformations (OR=1.17; CI: 1.06, 1.28) and of the first diagnosis of infection [hazard ratio (HR) = 1.28; CI: 1.17, 1.39], mental disorders (age 0-2.5 years: HR = 2.03; CI: 1.32, 3.14), and eye (age 0-4.5 years: HR = 1.27; CI: 1.06, 1.53), ear (HR = 1.36; CI: 1.23, 1.51), respiratory (HR = 1.27; CI; 1.19, 1.35), digestive (HR = 1.23; CI: 1.11, 1.37), skin (HR = 1.24; CI: 1.09, 1.43), musculoskeletal (HR = 1.15; CI: 1.01-1.30), and genitourinary diseases (HR = 1.25; CI; 1.08, 1.45). Emotional stress was associated with an increased risk for the first diagnosis of infection (HR = 1.09; CI: 1.01, 1.18) and a decreased risk for the first diagnosis of endocrine (HR = 0.81; CI; 0.67, 0.99), eye (HR = 0.84; CI; 0.71, 0.99), and circulatory diseases (age 0-3 years: HR = 0.63; CI: 0.42, 0.95).
conclusionsMaternal life stress during pregnancy may be a common risk factor for impaired child health. The results suggest new approaches to reduce childhood diseases.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.