Evidence map›Paper›PMID 21775009›Full record

Trial reportDiabetes research and clinical practice2011

Relative utility of 1-h Oral Glucose Tolerance Test as a measure of abnormal glucose homeostasis.

K J Joshipura, M O Andriankaja, F B Hu, C S Ritchie

Abstract readClinical TrialComparative Study
In one paragraph

Trial report in Diabetes research and clinical practice, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Longitudinal association between adiposity and inter-arm blood pressure difference.Journal of clinical hypertension (Greenwich, Conn.) · 2019
    Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Observational
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

K J JoshipuraUniversity of Puerto Rico, Center for Clinical Research and Health Promotion, School of Dental Medicine, Medical Sciences Campus, PO Box 365067, San Juan PR 00936, Puerto Rico; Harvard School of Public Health, Department of Epidemiology, 677 Huntington Avenue, Boston, MA 02115, United States. Electronic address: kaumudi.joshipura@upr.edu.
M O AndriankajaUniversity of Puerto Rico, Center for Clinical Research and Health Promotion, School of Dental Medicine, Medical Sciences Campus, PO Box 365067, San Juan PR 00936, Puerto Rico. Electronic address: oelisoa.andriankaja@gmail.com.
F B HuHarvard School of Public Health, Department of Epidemiology, 677 Huntington Avenue, Boston, MA 02115, United States. Electronic address: frank.hu@channing.harvard.edu.
C S RitchieBirmingham-Atlanta VA Geriatric Research, Education and Clinical Center (GRECC), University of Alabama at Birmingham, 1530 3rd Avenue South, Birmingham, AL 35294-2041, USA; University of Puerto Rico, Center for Clinical Research and Health Promotion, School of Dental Medicine, Medical Sciences Campus, PO Box 365067, San Juan PR 00936, Puerto Rico. Electronic address: CRitchie@aging.uab.edu.

Funding

SUPPLEMENT FOR RENOVATION OF ANIMAL FACILITIES AT INSTITUTE OF NEUROBIOLOGYG12RR003051 · NCRR · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI RODRIGUEZ, RAMONA · 1986 to 2011
$28.1M
TRANSLATIONAL PROTEOMICS CENTERG12MD007600 · NIMHD · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI FERNANDEZ-REPOLLET, EMMA · 2012 to 2016
$11.0M
Periodontitis and pre-clinical diabetesR01DE020111 · NIDCR · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI JOSHIPURA, KAUMUDI J, PEREZ, CYNTHIA MADELINE · 2010 to 2015
$3.1M
Clinical Research and Mentoring in Oral EpidemiologyK24DE016884 · NIDCR · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI JOSHIPURA, KAUMUDI J · 2005 to 2009
$758k
NCRR NIH HHS G12RR03051NIDCR NIH HHS K24 DE016884NIDCR NIH HHS K24DE16884NIDCR NIH HHS R01 DE020111NIMHD NIH HHS G12 MD007600
6 · The paper itself

Abstract

BACKGROUND AND

aimsImpaired glucose tolerance based on 2-h glucose levels is more predictive of future cardiovascular disease and more sensitive in detecting earlier diabetes compared to impaired fasting glucose. However, the 1-h OGTT may be even more sensitive than the 2-h. We assessed the relative value of 1-h OGTT by exploring its relationship with adiposity and other measures of glucose homeostasis. METHODS AND

resultsNinety four overweight/obese individuals free of diabetes and major cardiovascular conditions were included in the analyses. We adjusted for age, gender, smoking status and physical activity. One-h OGTT showed similar partial correlations with fasting glucose and 2-h OGTT (r=0.60 and 0.64 respectively). Fasting glucose, fasting insulin and HOMA correlated better with 1-h OGTT (r=0.60, 0.47 and 0.52) than with 2-h OGTT (r=0.50, 0.41, and 0.45). BMI and waist circumference also showed stronger correlation with 1-h (r=0.31, 0.29), compared to 2-h OGTT (r=0.16, 0.16) or fasting glucose (r=0.23, 0.22). Metabolic syndrome was associated similarly with 1-h and 2-h OGTT.

conclusionsThe 1-h OGTT correlates well with both fasting glucose and 2-h OGTT and shows similar or higher associations with obesity measures. The 1-h OGTT has potential utility in epidemiologic studies.

Indexed as

HomeostasisAdiposityAdultAgedBlood GlucoseBody Mass IndexFemaleGlucose Tolerance TestHumansInsulinMaleMetabolic SyndromeMiddle AgedTime FactorsWaist CircumferenceBlood GlucoseInsulin

Identifiers

PMID21775009
PMCPMC3156353

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.