Evidence map›Paper›PMID 21774991›Full record

ArticleJournal of affective disorders2012

Principal domains of quantitative anxiety trait in subjects with lifetime history of mania.

Javier Contreras, Elizabeth Hare, Michael Escamilla, Henriette Raventos

Abstract read
In one paragraph

Article in Journal of affective disorders, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 12 citations in OpenAlex.

  1. Family study of bipolar disorder with comorbid anxiety disorder points toPCN reports : psychiatry and clinical neurosciences · 2025
    Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Javier ContrerasSouth Texas Psychiatric Genetics Research Center, Texas Tech University Health Science Center, El Paso, TX, USA; Centro de Investigación en Biologia Celular y Molecular, University of Costa Rica, San Jose, Costa Rica. Electronic address: dr.javiercontreras@gmail.com.
Elizabeth HareSouth Texas Psychiatric Genetics Research Center, Texas Tech University Health Science Center, El Paso, TX, USA.
Michael EscamillaSouth Texas Psychiatric Genetics Research Center, Texas Tech University Health Science Center, El Paso, TX, USA.
Henriette RaventosCentro de Investigación en Biologia Celular y Molecular, University of Costa Rica, San Jose, Costa Rica.
Texas Tech University · USUniversidad de Costa Rica · CR

Funding

Genetics of Bipolar Disorder in Latino PopulationsR01MH069856 · NIMH · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI ESCAMILLA, MICHAEL A · 2005 to 2009
$6.5M
US/Costa Rica Psychiatric Genetic Research TrainingD43TW006152 · FIC · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI ESCAMILLA, MICHAEL A · 2002 to 2006
$2.0M
FIC NIH HHS D43 TW006152FIC NIH HHS TW006152NIMH NIH HHS 1 R01 MH069856-01A2NIMH NIH HHS R01 MH069856
6 · The paper itself

Abstract

backgroundHigh comorbidity rates for anxiety have been documented in subjects with history of mania or hypomania. We explored the presence of latent constructs of quantitative anxiety in subjects who have a history of mania or hypomania.

methodsWe conducted an exploratory factor analysis of anxiety trait in 212 subjects who have a lifetime history of at least one manic/hypomanic syndrome. Participants were originally recruited for a Costa Rican sibling pair genetic study of Bipolar Disorder. We used principal factors extraction method with squared multiple correlations (SAS/SAT Professional software) of the STAI (trait subscale).

resultsA three-factor solution with a good simple structure and statistical adequacy was obtained with a KMO of 0.84 (>0.6) and Bartlett's Test of Sphericity of 2.4668E-162 (p<0.05). Items were grouped into anxiety-absent factor and the anxiety-present symptoms in two additional factors based on the nature of the symptoms, worry and rumination. LIMITATIONS: Comorbid disorders could affect the interaction of anxiety score with manic/hypomanic symptoms. Some statistical parameters (mood status independence, score distribution and correlation between trait score and quantitative mania/hypomania) were not taken into consideration to extract the factors. Because anxiety dimensions were explored on individuals with history of mania or hypomania and not in healthy subjects, comparison of our results with other studies can draw confusing conclusions.

conclusionsTwo underlying constructs, worry and rumination may explain anxiety sub-syndromic symptoms in Costa Rican patients with history of mania or hypomania.

Indexed as

AdultAnxietyBipolar DisorderComorbidityFemaleHumansMaleMiddle AgedSiblings

Identifiers

PMID21774991
PMCPMC3940478
OpenAlexW1980828210

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.