ArticleJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2011
An integrative study ascertained SOD2 as a susceptibility gene for osteoporosis in Chinese.
Article in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 34 citations in OpenAlex.
- Sex-Specific Association Between Serum SOD Activity and Osteoporosis in Type 2 Diabetes: A Cross-Sectional Study with Functional Validation.Journal of clinical medicine · 2026Article
- Sirt3 Rescues Porphyromonas gingivalis-Impaired Cementogenesis via SOD2 Deacetylation.Cell proliferation · 2025Article
- Sirtuin 3-activated superoxide dismutase 2 mediates fluoride-induced osteoblastic differentiation in vitro and in vivo by down-regulating reactive oxygen species.Archives of toxicology · 2024Article
- Oxidative-Stress-Related Genes in Osteoporosis: A Systematic Review.Antioxidants (Basel, Switzerland) · 2023Review
- Association Between Antioxidant Nutrients, Oxidative Stress-Related Gene Polymorphism and Skeletal Fluorosis in Guizhou, China.Frontiers in public health · 2022Article
- Identification of osteoporosis based on gene biomarkers using support vector machine.Open medicine (Warsaw, Poland) · 2022Article
- A trans-ethnic two-stage polygenetic scoring analysis detects genetic correlation between osteoporosis and schizophrenia.Clinical and translational medicine · 2020Article
- A road map for understanding molecular and genetic determinants of osteoporosis.Nature reviews. Endocrinology · 2020Review
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- SIRT3/SOD2 maintains osteoblast differentiation and bone formation by regulating mitochondrial stress.Cell death and differentiation · 2018Article
- "Omics" Signatures in Peripheral Monocytes from Women with Low BMD Condition.Journal of osteoporosis · 2018Review
- Purinergic P2X7 receptor functional genetic polymorphisms are associated with the susceptibility to osteoporosis in Chinese postmenopausal women.Purinergic signalling · 2017Article
- Rapid phenotyping of knockout mice to identify genetic determinants of bone strength.The Journal of endocrinology · 2016Review
- Manganese superoxide dismutase is required to maintain osteoclast differentiation and function under static force.Scientific reports · 2015Article
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- Article
- Genome-wide Association Studies for Osteoporosis: A 2013 Update.Journal of bone metabolism · 2014Review
- Integrative analysis of multiple diverse omics datasets by sparse group multitask regression.Frontiers in cell and developmental biology · 2014Article
- Association between vitamin D receptor gene polymorphisms (Fok1 and Bsm1) and osteoporosis: a systematic review.Journal of diabetes and metabolic disorders · 2014Article
- Caspase-2 maintains bone homeostasis by inducing apoptosis of oxidatively-damaged osteoclasts.PloS one · 2014Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Osteoporosis is characterized by low BMD and has strong genetic determination. However, specific genetic variants influencing BMD and contributing to the pathogenesis of osteoporosis are largely uncharacterized. Current genetic studies in bone, which are aimed at identification of osteoporosis risk genes, are focused mostly on DNA, RNA, or the protein level individually, lacking integrative evidence from the three levels of genetic information flow to confidently ascertain the significance of genes for osteoporosis. Our previous proteomics study discovered that superoxide dismutase 2 (SOD2) in circulating monocytes (CMCs, ie, potential osteoclast precursors) was significantly upregulated at protein level in vivo in Chinese with low versus high hip BMD. Herein, at mRNA level, we found that SOD2 gene expression also was upregulated in CMCs (p < 0.05) in Chinese with low versus high hip BMD. At the DNA level, in 1627 unrelated Chinese subjects, we identified eight single-nucleotide polymorphisms (SNPs) at the SOD2 gene locus that were suggestively associated with hip BMD (peak signal at rs11968525, p = 0.048). Among the eight SNPs, three SNPs (rs7754103, rs7754295, and rs2053949) were associated with the SOD2 mRNA expression level (p < 0.05), suggesting that they are expression quantitative trait loci (eQTLs) regulating SOD2 gene expression. In conclusion, this integrative evidence from DNA, RNA, and protein levels support SOD2 as a susceptibility gene for osteoporosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.