ReviewJournal of cardiovascular translational research2011
Filamin-a-related myxomatous mitral valve dystrophy: genetic, echocardiographic and functional aspects.
Review in Journal of cardiovascular translational research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- The Role of Transforming Growth Factor-β Signaling in Myxomatous Mitral Valve Degeneration.Frontiers in cardiovascular medicine · 2022Pooled it
- Genomic analysis in patients with myxomatous mitral valve prolapse: current state of knowledge.BMC cardiovascular disorders · 2018Pooled it
- FLNA Mutations in Multisystem Disease: A Diagnostic Key for Unexplained Valvular and Connective Tissue Disorder.JACC. Case reports · 2025Article
- Biology of mitral valve prolapse: from general mechanisms to advanced molecular patterns-a narrative review.Frontiers in cardiovascular medicine · 2023Review
- Role of the Epicardium in the Development of the Atrioventricular Valves and Its Relevance to the Pathogenesis of Myxomatous Valve Disease.Journal of cardiovascular development and disease · 2021Review
- Macrophage lineages in heart valve development and disease.Cardiovascular research · 2021Review
- Periostin/Filamin-A: A Candidate Central Regulatory Axis for Valve Fibrogenesis and Matrix Compaction.Frontiers in cell and developmental biology · 2021Article
- Filamin-A as a Balance between Erk/Smad Activities During Cardiac Valve Development.Anatomical record (Hoboken, N.J. : 2007) · 2019Article
- Genetics of syndromic and non-syndromic mitral valve prolapse.Heart (British Cardiac Society) · 2018Review
- Imaging of Mitral Valve Prolapse: What Can We Learn from Imaging about the Mechanism of the Disease?Journal of cardiovascular development and disease · 2015Review
- New biomarkers for primary mitral regurgitation.Clinical proteomics · 2015Article
- Periostin induces intracellular cross-talk between kinases and hyaluronan in atrioventricular valvulogenesis.The Journal of biological chemistry · 2014Article
- Valvular dystrophy associated filamin A mutations reveal a new role of its first repeats in small-GTPase regulation.Biochimica et biophysica acta · 2014Article
- Genetics of valvular heart disease.Current cardiology reports · 2014Review
- Etiology of valvular heart disease-genetic and developmental origins.Circulation journal : official journal of the Japanese Circulation Society · 2014Review
- The role of pygopus in the differentiation of intracardiac valves in Drosophila.Genesis (New York, N.Y. : 2000) · 2014Article
- Developmental basis for filamin-A-associated myxomatous mitral valve disease.Cardiovascular research · 2012Article
- Atrioventricular valve development: new perspectives on an old theme.Differentiation; research in biological diversity · 2012Review
- Differentiating the aging of the mitral valve from human and canine myxomatous degeneration.Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology · 2012Review
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Myxomatous dystrophy of the cardiac valves is a heterogeneous group of disorders, including syndromic diseases such as Marfan syndrome and isolated valvular diseases. Mitral valve prolapse, the most common form of this disease, is presumed to affect approximately 2% to 3% of the population and remains one of the most common causes of valvular surgery. During the past years, important effort has been made to better understand the pathophysiological basis of mitral valve prolapse. Autosomal-dominant transmission is the usual inheritance with reduced penetrance and variable expressivity. Three loci have been mapped to chromosomes 16p11-p12, 11p15.4 and 13q31-32, but the underlying genetic defects are not currently known. An X-linked recessive form has been originally described by Monteleone and Fagan in 1969. Starting from one large French family and three smaller other families in which MVP was transmitted with an X-linked pattern, we have been able to identify three filamin A mutations p.Gly288Arg and p.Val711Asp and a 1,944-bp genomic deletion coding for exons 16 to 19. In this review, we describe the genetic, echocardiographic and functional aspects of the filamin-A-related myxomatous mitral valve dystrophy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.