Evidence map›Paper›PMID 21773848›Full record

ArticleJournal of general internal medicine2011

The comparative effectiveness of mail order pharmacy use vs. local pharmacy use on LDL-C control in new statin users.

Julie A Schmittdiel, Andrew J Karter, Wendy Dyer, Melissa Parker, Connie Uratsu, James Chan, O Kenrik Duru

Registry-linked trialAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of general internal medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02621476 (Encouraging Mail Order Pharmacy Use to Improve Outcomes and Reduce Disparities), which is not on this map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02621476 nacompletednot on this mapstarted 2017, after this paper: background citation

Encouraging Mail Order Pharmacy Use to Improve Outcomes and Reduce Disparities

TypeinterventionalSponsorKaiser PermanenteRan2017 to 2022Enrolled63,012ConditionsDiabetes MellitusArmsStandardized intervention, Usual care
3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  13. Student Pharmacists' Perceptions of Amazon Pharmacy.Pharmacy (Basel, Switzerland) · 2021
    Article
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  15. Review
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  17. Assessment of Consolidated Mail Outpatient Pharmacy Utilization in the Indian Health Service.Federal practitioner : for the health care professionals of the VA, DoD, and PHS · 2020
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Julie A SchmittdielDivision of Research, Kaiser Permanente Northern California, Oakland, CA 94612, USA. Julie.A.Schmittdiel@kp.org
Andrew J Karter
Wendy Dyer
Melissa Parker
Connie Uratsu
James Chan
O Kenrik Duru

Funding

Medication Adherence and Social Disparities in DiabetesR01DK080726 · NIDDK · KAISER FOUNDATION RESEARCH INSTITUTE · PI KARTER, ANDREW JOHN · 2009 to 2012
$1.5M
Mail-Order Pharmacy Use and Medication Adherence Among Older Adults with DiabetesK08AG033630 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DURU, OBIDIUGWU KENRIK · 2009 to 2013
$606k
NIA NIH HHS K08 AG033630NIDDK NIH HHS R01 DK080726PHS HHS U58/CCU923527-04-1
6 · The paper itself

Abstract

backgroundMail order pharmacies are commonly used to deliver CVD risk factor medications. Previous studies have shown that mail order pharmacy use is associated with greater medication adherence; however, no studies have examined whether mail order pharmacy use is related to improved CVD risk factor outcomes.

objectiveTo examine the comparative effectiveness of mail order pharmacy vs. local pharmacy use on LDL-C control in new statin users.

designObservational cohort study. PATIENTS: 100,298 adult Kaiser Permanente Northern California (KPNC) members who were new users of statins between January 1, 2005 and December 31, 2007. MEASUREMENTS: The main outcome measure was LDL-C control in the 3-15 month period after statin therapy was initiated.

resultsAfter adjustment for patient, clinical, and census-block characteristics, and for potential unmeasured differences between mail order and local KPNC pharmacy users with instrumental variables analysis, 85.0% of patients who used the mail order pharmacy to deliver their statin at any time achieved target LDL-C levels compared with 74.2% of patients who only used the local KPNC pharmacy to dispense the statin (p < 0.001). Greater adjusted rates of LDL-C control in mail order pharmacy users were seen across all gender and race/ethnicity subgroups.

conclusionsMail order pharmacy use was positively associated with LDL-C control in new statin users. Future research should continue to explore the relationship between mail order pharmacy use and outcomes, and address how to appropriately target mail order services to patients most likely to benefit without compromising patient choice, care, and safety.

Indexed as

AdultAgedAged, 80 and overCaliforniaCholesterol, LDLFemaleHumansHydroxymethylglutaryl-CoA Reductase InhibitorsHyperlipidemiasInsurance, Pharmaceutical ServicesMaleMiddle AgedPharmaciesPostal ServiceRetrospective StudiesTreatment OutcomeCholesterol, LDLHydroxymethylglutaryl-CoA Reductase Inhibitors

Identifiers

PMID21773848
PMCPMC3235607

What OpenQuestion holds

Texttitle and abstract
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.