ArticleClinical rheumatology2012
Retrospective study of 61 patients with adult-onset Still's disease admitted with fever of unknown origin in China.
Article in Clinical rheumatology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 39 citations in OpenAlex.
- Diagnostic Complexity of Adult-Onset Still's Disease in the Setting of Nosocomial Infection and Antibiotic Hypersensitivity.Case reports in immunology · 2026Article
- Adult-onset Still's disease and fever of unknown origin in India.Clinical and experimental medicine · 2023Article
- Proposal of a new diagnostic algorithm for adult-onset Still's disease.Clinical rheumatology · 2023Article
- New insights on multigenic autoinflammatory diseases.Therapeutic advances in musculoskeletal disease · 2022Review
- Characteristics and Clinical Value of 18F-FDG PET/CT in the Management of Adult-Onset Still's Disease: 35 Cases.Journal of clinical medicine · 2021Article
- Acute severe hepatitis in adult-onset Still's disease: case report and comprehensive review of a life-threatening manifestation.Clinical rheumatology · 2021Review
- Elderly-onset Still's Disease Complicated by Macrophage Activation Syndrome: A Case Report and Review of the Literature.Internal medicine (Tokyo, Japan) · 2020Article
- Clinical analysis of 215 consecutive cases with fever of unknown origin: A cohort study.Medicine · 2018Observational
- Epidemiological study of adult-onset Still's disease using a Japanese administrative database.Rheumatology international · 2016Article
- Myocarditis in adult-onset still disease.Medicine · 2014Review
- Adult-onset still disease: manifestations, treatment, outcome, and prognostic factors in 57 patients.Medicine · 2014Article
- Fever of unknown origin: report of 107 cases in a university hospital.International journal of clinical and experimental medicine · 2014Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adult-onset Still's disease (AOSD), as a category of connective tissue diseases, has about 5∼9% of fever of unknown origin (FUO) cases. Diagnosis of AOSD was challenging because of its nonspecific characteristics. The present study analyzed clinical manifestations and laboratory findings in a series of patients with AOSD from eastern China. Medical records of 61 patients admitted with FUO and with a discharge diagnosis of AOSD were retrospectively evaluated and analyzed with special focus on clinical manifestations and laboratory findings. Compared with previous reports, most features of our patients had a similar incidence rate. Rash (79%), arthralgia (80%), and sore throat (84%) were the most frequent clinical manifestations in our series. Leukocytosis (80%), elevated ESR (98%) and CRP (100%), negative ANA (90%) and RF (93%), and high ferritin level (94%) were the most sensitive laboratory findings in our patients. AOSD was not a rare reason of FUO in eastern China. Fever, arthralgia, rash, sore throat, leukocytosis, neutrophilia, elevated ESR and CRP, negative ANA and RF, and high ferritin level were the most common clinical features in our series. The lack of highly specific characteristic makes the diagnosis of AOSD difficult compared with other diseases in FUO.
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