ArticleDiabetologia2011
The threshold hypothesis: solving the equation of nurture vs nature in type 1 diabetes.
Article in Diabetologia, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed.
- Diabetes of Unclear Type in an Adolescent Boy With Multiple Islet-cell Autoantibody Positivity Successfully Managed With Glucagon-like Peptide-1 Receptor Agonist Alone: A Case Report.Canadian journal of diabetes · 2023Article
- Predicting the development of T1D and identifying its Key Performance Indicators in children; a case-control study in Saudi Arabia.PloS one · 2023Article
- Thyroid autoantibody distribution in patients with latent autoimmune diabetes in youth: a multicenter, national survey.Annals of translational medicine · 2022Article
- Review
- Article
- Toward an Improved Classification of Type 2 Diabetes: Lessons From Research into the Heterogeneity of a Complex Disease.The Journal of clinical endocrinology and metabolism · 2021Review
- Article
- De-coding genetic risk variants in type 1 diabetes.Immunology and cell biology · 2021Review
- Use of Induced Pluripotent Stem Cells to Build Isogenic Systems and Investigate Type 1 Diabetes.Frontiers in endocrinology · 2021Article
- Environmental Determinants of Type 1 Diabetes: From Association to Proving Causality.Frontiers in immunology · 2021Review
- The clinical consequences of heterogeneity within and between different diabetes types.Diabetologia · 2020Review
- Excess BMI Accelerates Islet Autoimmunity in Older Children and Adolescents.Diabetes care · 2020Article
- Genetics of Type 1 Diabetes Comes of Age.Diabetes care · 2020Article
- The Genetic Architecture of Type 1 Diabetes.Genes · 2017Review
- Oral Corticosterone Administration Reduces Insulitis but Promotes Insulin Resistance and Hyperglycemia in Male Nonobese Diabetic Mice.The American journal of pathology · 2017Article
- Elevated CD8 T cell responses in type 1 diabetes patients to a 13 amino acid coeliac-active peptide from α-gliadin.Clinical and experimental immunology · 2014Article
- Does the gut microbiota have a role in type 1 diabetes? Early evidence from humans and animal models of the disease.Diabetologia · 2012Review
- The pathogenesis and natural history of type 1 diabetes.Cold Spring Harbor perspectives in medicine · 2012Review
- Comparative genetics: synergizing human and NOD mouse studies for identifying genetic causation of type 1 diabetes.The review of diabetic studies : RDS · 2012Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
For more than 40 years, the contributions of nurture (i.e. the environment) and nature (i.e. genetics) have been touted for their aetiological importance in type 1 diabetes. Disappointingly, knowledge gains in these areas, while individually successful, have to a large extent occurred in isolation from each other. One reason underlying this divide is the lack of a testable model that simultaneously considers the contributions of genetic and environmental determinants in the formation of this and potentially other disorders that are subject to these variables. To address this void, we have designed a model based on the hypothesis that the aetiological influences of genetics and environment, when evaluated as intersecting and reciprocal trend lines based on odds ratios, result in a method of concurrently evaluating both facets and defining the attributable risk of clinical onset of type 1 diabetes. The model, which we have elected to term the 'threshold hypothesis', also provides a novel means of conceptualising the complex interactions of nurture with nature in type 1 diabetes across various geographical populations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.