ArticleJournal of pathology informatics2011
Modified full-field optical coherence tomography: A novel tool for rapid histology of tissues.
Article in Journal of pathology informatics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Differentiating malignancy from liver parenchyma in Ex-Vivo OCT images using anomaly detection.Scientific reports · 2026Article
- Label-free optical microscopy with artificial intelligence: a new paradigm in pathology.Biophotonics discovery · 2025Review
- Dynamic full-field optical coherence tomography module adapted to commercial microscopes allows longitudinal in vitro cell culture study.Communications biology · 2023Article
- Optical coherence tomography combined with convolutional neural networks can differentiate between intrahepatic cholangiocarcinoma and liver parenchyma ex vivo.Journal of cancer research and clinical oncology · 2023Article
- Interface self-referenced dynamic full-field optical coherence tomography.Biomedical optics express · 2023Article
- Optical coherence tomography and convolutional neural networks can differentiate colorectal liver metastases from liver parenchyma ex vivo.Journal of cancer research and clinical oncology · 2023Article
- Fractal-based aberration-corrected full-field OCT.Biomedical optics express · 2023Article
- Automatic diagnosis and classification of breast surgical samples with dynamic full-field OCT and machine learning.Journal of medical imaging (Bellingham, Wash.) · 2023Article
- Strategies in Infertile Azoospermic Patients with Negative Microdissection Testicular Sperm Extraction Surgery.Urology research & practice · 2023Article
- Article
- Optical coherence tomography holds promise to transform the diagnostic anatomic pathology gross evaluation process.Journal of biomedical optics · 2022Article
- Rapid pseudo-H&E imaging using a fluorescence-inbuilt optical coherence microscopic imaging system.Biomedical optics express · 2021Article
- Novel methods to enhance surgical sperm retrieval: a systematic review.Arab journal of urology · 2021Review
- The First In Vivo Needle-Based Optical Coherence Tomography in Human Prostate: A Safety and Feasibility Study.Lasers in surgery and medicine · 2019Article
- Probing dynamic processes in the eye at multiple spatial and temporal scales with multimodal full field OCT.Biomedical optics express · 2019Article
- Customized Tool for the Validation of Optical Coherence Tomography in Differentiation of Prostate Cancer.Technology in cancer research & treatment · 2017Article
- Assessment of collagen antibody-induced arthritis in BALB/c mice using bioimaging analysis and histopathological examination.Laboratory animal research · 2016Article
- The development of surgical sperm extraction and new challenges to improve the outcome.Reproductive medicine and biology · 2016Review
- Real-time cancer diagnosis during prostate biopsy: ex vivo evaluation of full-field optical coherence tomography (FFOCT) imaging on biopsy cores.World journal of urology · 2016Article
- Rapid evaluation of fresh ex vivo kidney tissue with full-field optical coherence tomography.Journal of pathology informatics · 2015Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHere, we report the first use of a commercial prototype of full-field optical coherence tomography called Light-CT™. Based on the principle of white light interferometry, Light-CT™ generates quick high-resolution three-dimensional tomographic images from unprocessed tissues. Its advantage over the current intra-surgical diagnostic standard, i.e. frozen section analysis, lies in the absence of freezing artifacts, which allows real-time diagnostic impressions, and/or for the tissues to be triaged for subsequent conventional histopathology. MATERIALS AND
methodsIn this study, we recapitulate known normal histology in nine formalin fixed ex vivo rat organs (skin, heart, lung, liver, stomach, kidney, prostate, urinary bladder, and testis). Large surface and virtually sectioned stacks of images at varying depths were acquired by a pair of 10×/0.3 numerical aperture water immersion objectives, processed and visualized in real time.
resultsNormal histology of the following organs was recapitulated by identifying various tissue microstructures. Skin: epidermis, dermal-epidermal junction and hair follicles with surrounding sebaceous glands in the dermis. Stomach: mucosa with surface pits, submucosa, muscularis propria and serosa. Liver: hepatocytes separated by sinusoidal spaces, central veins and portal triad. Kidney: convoluted tubules, medullary rays (straight tubules) and collecting ducts. Prostate: acini and fibro-muscular stroma. Lung: bronchi, bronchioles, alveolar ducts, alveoli and pleura. Urinary bladder: urothelium, lamina propria, muscularis propria, and serosa. Testis: seminiferous tubules with intra-tubular sperms.
conclusionLight-CT™ is a powerful imaging tool to perform fast histology on fresh and fixed tissues, without introducing artifacts. Its compact size, ease of handling, fast image acquisition and safe incident light levels makes it well-suited for various intra-operative and intra-procedural triaging and decision making applications.
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