ArticlePharmacognosy research2011
Screening for estrogenic and antiestrogenic activities of plants growing in Egypt and Thailand.
Article in Pharmacognosy research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 28 citations in OpenAlex.
- Evaluating Potential Effects of Chamomile (Food science & nutrition · 2026Review
- Examining the Effect of Chamomile on Clinical Symptoms and Hormonal Parameters Among Patients With Polycystic Ovarian Syndrome.Journal of family & reproductive health · 2022Article
- Estrogenic, Antiestrogenic and Antiproliferative Activities ofNutrients · 2019Article
- Effect of methanolic crude extract of Aframomum melegueta (A.m) seeds on selected lactogenic hormones of Albino rats.International journal of biochemistry and molecular biology · 2019Article
- Phenolics Isolated from Aframomum meleguta Enhance Proliferation and Ossification Markers in Bone Cells.Molecules (Basel, Switzerland) · 2017Article
- In Vivo and In Vitro Evaluation of Pharmacological Potentials of Secondary Bioactive Metabolites ofEvidence-based complementary and alternative medicine : eCAM · 2017Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere is a growing demand for the discovery of new phytoestrogens to be used as a safe and effective hormonal replacement therapy. MATERIALS AND
methodsThe methanol extracts of 40 plants from the Egyptian and Thailand folk medicines were screened for their estrogen agonist and antagonist activities. The estrogenic and antiestrogenic effects of the tested extracts were carried out using the yeast two-hybrid assay system expressing ERα and ERβ. In addition, all the extracts were subjected to a naringinase treatment and retested for their estrogenic activity.
resultsThe methanol extracts of Derris reticulata and Dracaena lourieri showed the most potent estrogenic activity on both estrogen-receptor subtypes, while, the methanol extracts of Butea monosperma, Erythrina fusca, and Dalbergia candenatensis revealed significant estrogenic activity on ERβ only. Nigella sativa, Sophora japonica, Artabotrys harmandii, and Clitorea hanceana showed estrogenic effect only after naringinase treatment. The most potent antiestrogenic effect was revealed by Aframomum melegueta, Dalbergia candenatensis, Dracena loureiri, and Mansonia gagei.
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